52427-09-5

Basic information

• Product Name: (2-hydroxy-5-nitro-phenoxy)-acetic acid
• Synonyms: (2-hydroxy-5-nitro-phenoxy)-acetic acid
• CAS NO: 52427-09-5
• Molecular Weight: 213.147
• Mol File: 52427-09-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (2-hydroxy-5-nitro-phenoxy)-acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2-hydroxy-5-nitro-phenoxy)-acetic acid(52427-09-5)
• EPA Substance Registry System: (2-hydroxy-5-nitro-phenoxy)-acetic acid(52427-09-5)

Safety Data

• Hazardous Substances Data: 52427-09-5(Hazardous Substances Data)

Usage

General Description

(2-hydroxy-5-nitro-phenoxy)-acetic acid, also known as 2-hydroxy-5-nitrophenoxyacetic acid, is a chemical compound with the molecular formula C8H7NO6. It is a nitrophenyl derivative of acetic acid and is commonly used as a herbicide. This chemical has the potential to control a range of broadleaf weeds and grasses, making it a popular choice for agricultural and industrial applications. It works by inhibiting the growth of unwanted plants through disruption of their natural processes. However, it is important to handle this chemical with care as it can be toxic to humans and other living organisms if not used properly.

Upstream product

• 636-93-1 5-nitroguaiacol 
• 79-11-8 chloroacetic acid 
• 3316-09-4 1,2-dihydroxy-4-nitrobenzene 
• 52427-04-0 2-Brom-5-nitrophenoxyessigsaeure 
• 52427-05-1 2-bromo-5-nitrophenol 
• 6324-11-4 2-(2-hydroxyphenoxy)acetic acid 

Downstream Products

• 56913-09-8 (5-chloro-2-methoxy-phenoxy)-acetic acid 
• 103440-70-6 2-(2-methoxy-5-nitrophenoxy)acetic acid 
• 328104-87-6 (5-chloro-2-hydroxy-phenoxy)-acetic acid 

Relevant articles and documents

Engineering Orthogonal Methyltransferases to Create Alternative Bioalkylation Pathways

S-adenosyl-l-methionine (SAM)-dependent methyltransferases (MTs) catalyse the methylation of a vast array of small metabolites and biomacromolecules. Recently, rare carboxymethylation pathways have been discovered, including carboxymethyltransferase enzymes that utilise a carboxy-SAM (cxSAM) cofactor generated from SAM by a cxSAM synthase (CmoA). We show how MT enzymes can utilise cxSAM to catalyse carboxymethylation of tetrahydroisoquinoline (THIQ) and catechol substrates. Site-directed mutagenesis was used to create orthogonal MTs possessing improved catalytic activity and selectivity for cxSAM, with subsequent coupling to CmoA resulting in more efficient and selective carboxymethylation. An enzymatic approach was also developed to generate a previously undescribed co-factor, carboxy-S-adenosyl-l-ethionine (cxSAE), thereby enabling the stereoselective transfer of a chiral 1-carboxyethyl group to the substrate.