6324-11-4

Usage

Uses

Used in Skincare Industry:
2-Hydroxyphenoxyacetic acid is used as an exfoliating agent for its ability to loosen and remove dead skin cells from the skin's surface, promoting cell turnover and leading to smoother, brighter, and more youthful-looking skin.
2-Hydroxyphenoxyacetic acid is used as an anti-aging ingredient for its collagen-stimulating properties, which help reduce the appearance of fine lines and wrinkles.
2-Hydroxyphenoxyacetic acid is used as a skin brightening agent to improve the appearance of hyperpigmentation and uneven skin tone.
2-Hydroxyphenoxyacetic acid is used as an acne treatment ingredient for its ability to unclog pores and reduce the occurrence of breakouts.
Overall, 2-Hydroxyphenoxyacetic acid is a highly effective and popular ingredient in many skincare formulations, offering a range of benefits for maintaining healthy and youthful skin.

InChI:InChI=1/C8H8O4/c9-6-3-1-2-4-7(6)12-5-8(10)11/h1-4,9H,5H2,(H,10,11)

Upstream product

• 120-80-9 benzene-1,2-diol 
• 79-11-8 chloroacetic acid 
• 34789-97-4 pyrocatechol monosodium salt 
• 105-36-2 ethyl bromoacetate 
• 99186-63-7 ethyl 2-(2-hydroxyphenoxy)acetate 
• 93533-86-9 [2,2']bi[benzo[1,3]dioxolyl] 
• 7664-93-9 sulfuric acid 

Downstream Products

• 165380-12-1 2-(methoxycarbonyl)methoxyphenol 
• 4385-48-2 1,4-benzodioxan-2-one 
• 52427-09-5 (2-hydroxy-5-nitro-phenoxy)-acetic acid 
• 112937-75-4 (2-hydroxy-3,5-dinitrophenoxy)acetic acid 
• 101421-92-5 (3-Nitro-2-hydroxy-phenoxy)-essigsaeure 
• 120-80-9 benzene-1,2-diol 
• 34920-07-5 5-bromo-2-hydroxyphenoxyacetic acid 
• 1607018-33-6 2-((3-(pyridin-4-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl)methoxy)phenol 
• 1093409-05-2 KNI-10369 
• 847149-15-9 {2-[2-chloro-4-(methylsulfonyl)phenoxy]phenoxy}acetic acid 
• 103095-47-2 (2-hydroxy-5-nitrophenoxy)acetic acid ethyl ester 
• 103096-25-9 (3-Nitro-2-hydroxy-phenoxy)-essigsaeure-aethylester 
• 103440-70-6 2-(2-methoxy-5-nitrophenoxy)acetic acid 
• 34919-87-4 (2-hydroxyphenoxy)acetamide 

Relevant academic research and scientific papers

Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin

Plasmepsin (Plm) is a potential target for new antimalarial drugs, but most reported Plm inhibitors have relatively low antimalarial activities. We synthesized a series of dipeptide-type HIV protease inhibitors, which contain an allophenylnorstatine-dimethylthioproline scaffold to exhibit potent inhibitory activities against Plm II. Their activities against Plasmodium falciparum in the infected erythrocyte assay were largely different from those against the target enzyme. To improve the antimalarial activity of peptidomimetic Plm inhibitors, we attached substituents on a structure of the highly potent Plm inhibitor KNI-10006. Among the derivatives, we identified alkylamino compounds such as 44 (KNI-10283) and 47 (KNI-10538) with more than 15-fold enhanced antimalarial activity, to the sub-micromolar level, maintaining their potent Plm II inhibitory activity and low cytotoxicity. These results suggest that auxiliary substituents on a specific basic group contribute to deliver the inhibitors to the target Plm.

1,4-Benzodioxin-2(3H)-one and Some of its Derivatives

The methods of synthesis of 1,4-benzodioxin-2(3H)-one have been reexamined.Frequently quoted in the literature the method of Ghosh has been found to give impure (2-hydroxyphenoxy)acetic acid rather than the lactone.Using various methods some simple derivatives of the title lactone substituted in the benzene ring have been prepared and characterized.The bromination of the lactone with NBS gives predominantly 7-bromo-1,4-benzodioxin-2(3H)-one under electrophilic conditions, while 6-bromo-1,4-benzodioxin-2(3H)-one is obtained as a major isomer under photolytic conditions.