524698-46-2

Basic information

• Product Name: 2,2-dimethyl-3-phenyl-1-propyl p-methoxybenzenesulfonate
• Synonyms: 2,2-dimethyl-3-phenyl-1-propyl p-methoxybenzenesulfonate
• CAS NO: 524698-46-2
• Molecular Weight: 334.436
• Mol File: 524698-46-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,2-dimethyl-3-phenyl-1-propyl p-methoxybenzenesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-dimethyl-3-phenyl-1-propyl p-methoxybenzenesulfonate(524698-46-2)
• EPA Substance Registry System: 2,2-dimethyl-3-phenyl-1-propyl p-methoxybenzenesulfonate(524698-46-2)

Safety Data

• Hazardous Substances Data: 524698-46-2(Hazardous Substances Data)

Upstream product

• 13351-61-6 2,2-dimethyl-3-phenyl-1-propanol 
• 98-68-0 4-methoxy-phenyl-sulphonyl chloride 

Downstream Products

• 92-94-4 [1,1';4',1'']terphenyl 
• 613-37-6 4-methoxylbiphenyl 
• 53040-92-9 4-(4-tolyl)anisole 
• 97295-31-3 1,4-bis(p-tolyl)benzene 

Relevant articles and documents

Nickel(0)-catalyzed cross-coupling of alkyl arenesulfonates with aryl Grignard reagents

The nickel-catalyzed cross-coupling reactions of neopentyl arenesulfonates with arylmagnesium bromides, involving nucleophilic aromatic substitution of alkyloxysulfonyl groups by aryl nucleophiles, take place in high yields. Optimal efficiencies are obtained by adding 3 + 2 equiv of the Grignard reagent to a mixture of dppfNiCl2 and the sulfonate in refluxing THF. Neopentyl arenesulfonates are useful sources of the electrophilic aryl groups in these transition metal-catalyzed cross-coupling reactions. Aryl sulfonates are inappropriate due to their ambident reactivity under the reaction conditions. This new cross-coupling reaction can be used for the creative elimination of alkyloxysulfonyl groups from aromatic compounds and for the preparation of unsymmetric terphenyls and oligophenyls.