52489-34-6Relevant academic research and scientific papers
Construction of Benzofuran-3(2 H)-one Scaffolds with a Quaternary Center via Rh/Co Relay Catalyzed C-H Functionalization/Annulation of N-Aryloxyacetamides and Propiolic Acids
Yuan, Wen-Kui,Zhu, Ming-Hui,Geng, Rui-Sen,Ren, Guang-Yi,Zhang, Lin-Bao,Wen, Li-Rong,Li, Ming
supporting information, p. 1654 - 1658 (2019/03/11)
An unprecedented synthesis of valuable benzofuran-3(2H)-one scaffolds with a quaternary center was developed via Rh/Co relay catalyzed C-H functionalization/annulation of N-aryloxyacetamides with propiolic acids in moderate to good yields. The reaction features the simultaneous construction of the benzofuran motif containing a C2 quaternary center and a C3 carbonyl group. The preliminary mechanism study verified that the O atom of C3 carbonyl group originates from molecular oxygen.
6-(Aryl-amido or aryl-amidomethyl)-naphthalen-2-yloxy-acidic derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1)
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, (2008/06/13)
This invention provides novel compounds, pharmaceutical compositions and methods of treating thrombotic disorders in mammals, the compounds having the formula: Wherein: Ar is phenyl, naphthyl, furanyl, benzofuranyl, indolyl, pyrazolyl, oxazolyl, fluorenyl, phenylcycloalkane where the cycloalkane can be cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl and Ar can be optionally substituted by 1 to 3 groups selected from C1-C6 alkyl, C1-C6 alkoxy, hydroxy, phenyl-(CH2)0-6—, phenyl-(CH2)0-6O—, C3-C6 cycloalkyl, —(CH2)—C3-C6 cycloalkyl, halogen, C1-C3 perflouroalkyl and C1-C3 perfluoroalkoxy where phenyl can be substituted with from 1 to 3 groups selected from C1-C6 alkyl, C1-C6 alkoxy, phenyl, halogen, trifluoromethyl or trifluoromethoxy; R1 is hydrogen, C1-C6 alkyl or phenyl-(CH2)1-6— where phenyl can be substituted with C1-C6 alkyl, C1-C6 alkoxy, halo, trifluoromethyl or trifluoromethoxy; R2 and R3 are H, C1-C6 alkyl, phenyl-(CH2)0-3—, halo and C1-C3 perfluoroalkyl where phenyl can be substituted with C1-C6 alkyl, C1-C6 alkoxy, halo, trifluoromethyl or trifluoromethoxy; R4 is —CHR5CO2H or —CH2-tetrazole where R5 is H or benzyl; and n=0 or 1; or a pharmaceutically acceptable salt or ester form thereof.
METHODS FOR THE HOMOLOGATION OF BENZOFURANCARBOXYLIC ACIDS USING DIANIONIC INTERMEDIATES
Buttery, Cheryl D.,Knight, David W.,Nott, Andrew P.
, p. 4127 - 4130 (2007/10/02)
Dianions (2), (5), and (10), can be derived from the corresponding benzofurancarboxylic acids using lithium diisopropylamide, and are useful intermediates for the homologation of the parent acids.
