26537-68-8

Usage

Uses

Used in Pharmaceutical Industry:
1-Benzofuran-3-carboxylic acid is used as a building block for the synthesis of various bioactive molecules and pharmaceutical drugs. Its unique structure allows for the creation of diverse compounds with potential therapeutic effects.
Used in Antitumor Applications:
1-Benzofuran-3-carboxylic acid is used as an anti-tumor agent for its potential to inhibit the growth and progression of cancer cells. Its molecular structure allows it to interact with cellular targets, modulating signaling pathways and mechanisms that contribute to tumor development.
Used in Antioxidant Applications:
1-Benzofuran-3-carboxylic acid is used as an antioxidant, leveraging its chemical properties to neutralize reactive oxygen species and protect cells from oxidative damage, which is implicated in various diseases and aging processes.
Used in Anti-inflammatory Applications:
1-Benzofuran-3-carboxylic acid is used as an anti-inflammatory agent, potentially reducing inflammation by modulating the activity of inflammatory mediators and pathways, which can be beneficial in treating conditions characterized by chronic inflammation.
Used in Neurological Disorder Therapy:
1-Benzofuran-3-carboxylic acid is used in the development of new therapies for neurological disorders, as its properties are being investigated for potential neuroprotective and restorative effects on the nervous system, offering hope for the treatment of conditions such as Alzheimer's, Parkinson's, and other neurodegenerative diseases.

InChI:InChI=1/C9H6O3/c10-9(11)7-5-12-8-4-2-1-3-6(7)8/h1-5H,(H,10,11)

Upstream product

• 59214-70-9 3-bromobenzofuran 
• 109-72-8 n-butyllithium 
• 60-29-7 diethyl ether 
• 131-76-0 1-benzofuran-2,3-dicarboxylic acid 
• 93334-77-1 (2-carboxymethoxy-phenyl)-glyoxylic acid 
• 4687-25-6 1-benzofuran-3-carbaldehyde 
• 194278-43-8 benzofuran-3-carboxylic acid ethyl ester 
• 91-22-5 quinoline 
• 129-92-0 3-ethoxycarbonylbenzofuran-2-carboxylic acid 
• 4687-24-5 benzofuran-3-carboxylic acid methyl ester 
• 124-38-9 carbon dioxide 
• 40800-90-6 3-(α-methoxy)methylene benzofuran-2-(3H)-ketone 
• 859979-88-7 (2-methoxycarbonylmethoxy-phenyl)-glyoxylic acid methyl ester 
• 4732-72-3 coumarandione 

Downstream Products

• 271-89-6 1-benzofurane 
• 111964-21-7 benzo[b]furan-3-carbonyl chloride 
• 119-84-6 C₆H₄(CH₂CH₂C(O)O) 
• 66611-15-2 3-acetylbenzo[b]furan 
• 84993-49-7 2-hydroxy(phenyl)methylbenzofuran-3-carboxylic acid 
• 52489-34-6 2-ethylbenzofuran-3-carboxylic acid 
• 3265-74-5 2-methyl-1-benzofuran-3-carboxylic acid 
• 4687-23-4 3-hydroxymethylbenzofuran 
• 39891-55-9 2,3-dihydrobenzo[b]furan-3-carboxylic acid 
• 4687-25-6 1-benzofuran-3-carbaldehyde 
• 28222-80-2 3-(4-methoxybenzoyl)benzofuran 
• 64175-51-5 2-(3-benzofuranyl)acetic acid 
• 82156-58-9 benzofuran-3-yl-acetic acid ethyl ester 
• 959304-51-9 benzofuran-3-carboxamide 

Relevant academic research and scientific papers

A benzofuran -3 - carboxylic acid (by machine translation)

The invention relates to a benzofuran - 3 - carboxylic acid preparation method, the method using the intermediate 1 as raw materials, under alkaline conditions in the open-loop, the closed-loop process for preparing benzofuran - 3 - carboxylic acid. The method is characterized in that the mild reaction conditions, the operation is simple, high yield, is suitable for industrial production. (by machine translation)

2-Oxo-Driven Coupling Reactions of 2-Oxo Aldehydes/2-Oxo Iminium Ions and Hydroperoxides at Room Temperature

An efficient 2-oxo-group-promoted direct coupling reaction between 2-oxo aldehydes and hydroperoxides has been developed. The method has been used successfully for the generation of different 2-oxo esters and acids. This reaction harnesses the hydrogen-bonding-induced self-decomposition tendency of hydroperoxides; the intermediates produced by this process then attack the aldehyde or iminium ion to generate cross-coupled products either by direct coupling or by an amine-catalysed pathway. No external oxidants or metal catalysts are required for our method, and the reaction takes place at room temperature.

ANTI-HIV COMPOUNDS

Thiazole derivatives represented by Formula (I) are disclosed, where R1, R2, R3, A, X, Y, Z, R6 and R7 are disclosed herein. These thiazole derivatives and pharmaceutical compositions comprising these derivatives are useful in the treatment of HIV mediated diseases and conditions.

Silver-catalyzed protodecarboxylation of heteroaromatic carboxylic acids

[Chemical Equation Presented] A simple and highly efficient protodecarboxylation procedure for a variety of heteroaromatic carboxylic acids catalyzed by Ag2CO3 and AcOH in DMSO is described. This methodology can also perform the selective monoprotodecarboxylation of several aromatic dicarboxylic acids.

NOVEL INDOL CARBOXYLIC ACID BISPYRIDYL CARBOXAMIDE DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PREPARATION METHOD AND COMPOSITION CONTAINING THE SAME AS AN ACTIVE INGREDIENT

Disclosed herein are a new indole carboxylic acid bispyridyl carboxamide derivative, a preparation method thereof, and a composition for prevention or treatment of obesity, urinary disorders, and CNS disorders, containing the same as an active ingredient. Because the indole carboxylic acid bispyridyl carboxamide derivatives according to the present invention have high affinity for 5-HT2c receptors, act selectively on the 5-HT2c receptors, the derivatives rarely have adverse effects caused by other receptors. Because the derivatives effectively inhibit serotonin activity, they may be useful for treatment or prevention of obesity; urinary disorders such as urinary incontinence, premature ejaculation, erectile dysfunction, and prostatic hyperplasia; CNS disorders such as depression, anxiety, concern, panic disorder, epilepsy, obsessive-compulsive disorder, migraine, sleep disorder, withdrawal from drug abuse, Alzheimer's disease, and schizophrenia, associated with 5-HT2c receptors.

Novel indol carboxylic acid bispyridyl carboxamide derivatives as 5-HT2c receptor antagonists

Disclosed herein are a new indole carboxylic acid bispyridyl carboxamide derivative, a preparation method thereof, and a composition for prevention or treatment of obesity, urinary disorders, and CNS disorders, containing the same as an active ingredient. Because the indole carboxylic acid bispyridyl carboxamide derivatives according to the present invention have high affinity for 5-HT2c receptors, act selectively on the 5-HT2c receptors, the derivatives rarely have adverse effects caused by other receptors. Because the derivatives effectively inhibit serotonin activity, they may be useful for treatment or prevention of obesity; urinary disorders such as urinary incontinence, premature ejaculation, erectile dysfunction, and prostatic hyperplasia; CNS disorders such as depression, anxiety, concern, panic disorder, epilepsy, obsessive-compulsive disorder, migraine, sleep disorder, withdrawal from drug abuse, Alzheimer's disease, and schizophrenia, associated with 5-HT2c receptors.

Synthesis and structure-activity relationship of 1H-indole-3-carboxylic acid pyridine-3-ylamides: A novel series of 5-HT2C receptor antagonists

A novel series of 1H-indole-3-carboxylic acid pyridine-3-ylamides were synthesized and identified to show high affinity and selectivity for 5-HT2C receptor. Among them, 1H-indole-3-carboxylic acid[6-(2-chloro-pyridin-3-yloxy)-pyridin-3-yl]-amide (15k) exhibits the highest affinity (IC50 = 0.5 nM) with an excellent selectivity (>2000 times) over other serotonin (5-HT1A, 5-HT2A, and 5-HT6) and dopamine (D2-D4) receptors.

PHENYL DIAZEPANE CARBOXAMIDES AND ANNELATED PHENYL PIPERAZINE CARBOXAMIDES CONTAINING OXYGEN AND USED AS DOPAMINE D3 ANTAGONISTS

The invention relates to annelated phenyl piperazine and phenyl diazepane carboxamides of general formula (I) containing oxygen.The compounds are suitable for medical purposes.

AZABICYCLO-OCTANE INHIBITORS OF IAP

The invention provides novel inhibitors of IAP that are useful as a therapeutic agents for treating malignancies where the compounds have the general formula (I) in which X1 and X2 are independently O or S; L is a bond or -C(X3

Preparation of 2,3-Dimethylene-2,3-dihydrobenzofuran by the Flash Vacuum Pyrolysis of (2-Methyl-3-benzofuryl)methyl Benzoate

Pyrolysis of (2-methyl-3-benzofuryl)methyl benzoate (7) gives a 30percent yield of two dimers of 2,3-dimethylene-2,3-dihydrobenzofuran (4), a dimer 12 and a dimer (13), in a ratio of 4.1 to 1.It is shown, by low-temperature 1H-NMR spectroscopy, that the primary pyrolysis product from 7 is 4, which forms 12 and 13 upon warming.The structure of the dimer 12 is confirmed by a deuterium-labeling experiment.Compound 4 can be trapped with methyl acrylate to form a 3.0 to 1 ratio of two Diels-Alder adducts.