5249-68-3

Basic information

• Product Name: tert-Butyl 4-benzyloxycarbonylamino-N-(2-methoxy-1-methyl-2-oxoethyl)glutaramate
• Synonyms: (4S)-4-(Benzyloxycarbonylamino)-5-[[(S)-2-methoxy-1-methyl-2-oxoethyl]amino]-5-oxopentanoic acid tert-butyl ester;tert-Butyl 4-benzyloxycarbonylamino-N-(2-methoxy-1-methyl-2-oxoethyl)glutaramate;Z-5-(tert-Butyloxy)-5-oxo-L-Nva-L-Ala-OMe
• CAS NO: 5249-68-3
• Molecular Formula: C₂₁H₃₀N₂O₇
• Molecular Weight: 422.47
• Mol File: 5249-68-3.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: tert-Butyl 4-benzyloxycarbonylamino-N-(2-methoxy-1-methyl-2-oxoethyl)glutaramate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-Butyl 4-benzyloxycarbonylamino-N-(2-methoxy-1-methyl-2-oxoethyl)glutaramate(5249-68-3)
• EPA Substance Registry System: tert-Butyl 4-benzyloxycarbonylamino-N-(2-methoxy-1-methyl-2-oxoethyl)glutaramate(5249-68-3)

Safety Data

• Hazardous Substances Data: 5249-68-3(Hazardous Substances Data)

Upstream product

• 25529-35-5 pentafluorophenyl N-benzyloxycarbonyl-γ-tert-butyl-L-glutamate 
• 2491-20-5 L-alanine methyl ester hydrochloride 
• 56877-41-9 methyl 2(S)-2-benzyloxycarbonylamino-4-tert-butoxycarbonylbutanoate 
• 3886-08-6 5-tert-butyl N-benzyloxycarbonyl-L-glutamate 
• 10065-72-2 L-Alanine methyl ester 
• 133010-26-1 (S)-4-benzyloxycarbonylamino-4-fluorocarbonylbutyric acid tert-butyl ester 
• 6233-91-6 N-Benzyloxycarbonyl-γ-tert.-butyl-L-glutaminsaeure-pentachlor-phenyl-diester 

Downstream Products

• 81660-29-9 N-benzyloxycarbonyl-L-leucyl-L-valyl-γ-tert-butyl-L-glutamyl-L-alanine methyl ester 
• 13409-17-1 N-benzyloxycarbonyl-L-valyl-γ-tert-butyl-L-glutamyl-L-alanine methyl ester 
• 6234-04-4 N-Benzyloxycarbonyl-γ-tert.-butyl-L-glutamyl-L-alanin-hydrazid 

Relevant articles and documents

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Synthesis of peptides employing protected-amino acid halides mediated by commercial anion exchange resin

Coupling of protected-amino acid halides (chloride, fluoride) mediated by commercial anion exchange resin for the solution phase synthesis of peptides is described. The reaction was carried out in an organic medium, circumventing the use of an organic base or an inorganic base. The coupling is fast, clean and racemization free. The anion exchange resin functions as a solid-phase basic scavenger, soaking up the HCl produced and allowing the amine to react. The method is extended for the coupling of sterically hindered α,α,- dialkylamino acids. Graphical Abstract: [Figure not available: see fulltext.]

NATURAL PEPTIDES AND THEIR ANALOGS XXV. SYNTHESIS OF PARTIALLY PROTECTED PEPTIDES CORRESPONDING TO THE B9-14 AND B15-20 FRAGMENTS OF HUMAN INSULIN

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