5249-68-3

Upstream product

• 6233-91-6 N-Benzyloxycarbonyl-γ-tert.-butyl-L-glutaminsaeure-pentachlor-phenyl-diester 
• 2491-20-5 L-alanine methyl ester hydrochloride 
• 25529-35-5 pentafluorophenyl N-benzyloxycarbonyl-γ-tert-butyl-L-glutamate 
• 10065-72-2 L-Alanine methyl ester 
• 3886-08-6 5-tert-butyl N-benzyloxycarbonyl-L-glutamate 
• 56877-41-9 methyl 2(S)-2-benzyloxycarbonylamino-4-tert-butoxycarbonylbutanoate 
• 133010-26-1 (S)-4-benzyloxycarbonylamino-4-fluorocarbonylbutyric acid tert-butyl ester 

Downstream Products

• 6234-04-4 N-Benzyloxycarbonyl-γ-tert.-butyl-L-glutamyl-L-alanin-hydrazid 
• 81660-29-9 N-benzyloxycarbonyl-L-leucyl-L-valyl-γ-tert-butyl-L-glutamyl-L-alanine methyl ester 
• 13409-17-1 N-benzyloxycarbonyl-L-valyl-γ-tert-butyl-L-glutamyl-L-alanine methyl ester 

Relevant academic research and scientific papers

Macrocyclization of Peptide Side Chains by the Ugi Reaction: Achieving Peptide Folding and Exocyclic N-Functionalization in One Shot

The cyclization of peptide side chains has been traditionally used to either induce or stabilize secondary structures (β-strands, helices, reverse turns) in short peptide sequences. So far, classic peptide coupling, nucleophilic substitution, olefin metat

Synthesis of peptides employing protected-amino acid halides mediated by commercial anion exchange resin

Coupling of protected-amino acid halides (chloride, fluoride) mediated by commercial anion exchange resin for the solution phase synthesis of peptides is described. The reaction was carried out in an organic medium, circumventing the use of an organic base or an inorganic base. The coupling is fast, clean and racemization free. The anion exchange resin functions as a solid-phase basic scavenger, soaking up the HCl produced and allowing the amine to react. The method is extended for the coupling of sterically hindered α,α,- dialkylamino acids. Graphical Abstract: [Figure not available: see fulltext.]

tert-Butyloxycarbonyl and Benzyloxycarbonyl Amino Acid Fluorides. New, Stable Rapid-Acting Acylating Agents for Peptide Synthesis

A new class of rapid-acting acylating agents, α-BOC and Z amino acid fluorides are obtained as stable, often crystalline, compounds by treatment of the protected amino acid cyanuric fluoride.