52497-69-5 Usage
Uses
Used in Pharmaceutical Industry:
ETHYL-(2-PHENYL-PROPYL)-AMINE is used as a chemical intermediate for the synthesis of various pharmaceuticals, contributing to the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical sector, ETHYL-(2-PHENYL-PROPYL)-AMINE is employed as an intermediate in the production of agrochemicals, aiding in the creation of compounds that protect crops and enhance agricultural productivity.
Used in Organic Compounds Synthesis:
ETHYL-(2-PHENYL-PROPYL)-AMINE is used as a building block in the preparation of different amines and nitrogen-containing compounds, which are essential in the synthesis of a wide range of organic compounds.
Used in Rubber Chemicals Production:
ETHYL-(2-PHENYL-PROPYL)-AMINE is used as an intermediate in the production of rubber chemicals, playing a role in the development of materials that enhance the performance and durability of rubber products.
Used in Antioxidants Production:
ETHYL-(2-PHENYL-PROPYL)-AMINE is also utilized in the production of antioxidants, which are crucial in preventing the oxidation of materials and extending their shelf life, particularly in the plastics and rubber industries.
Used in Specialty Chemicals Industry:
ETHYL-(2-PHENYL-PROPYL)-AMINE finds application as an intermediate in the manufacturing of specialty chemicals, which are used in various niche applications across different industries.
Check Digit Verification of cas no
The CAS Registry Mumber 52497-69-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,2,4,9 and 7 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 52497-69:
(7*5)+(6*2)+(5*4)+(4*9)+(3*7)+(2*6)+(1*9)=145
145 % 10 = 5
So 52497-69-5 is a valid CAS Registry Number.
52497-69-5Relevant academic research and scientific papers
Synthesis of β-Chiral Amines by Dynamic Kinetic Resolution of α-Branched Aldehydes Applying Imine Reductases
Matzel, Philipp,Wenske, Sebastian,Merdivan, Simon,Günther, Sebastian,H?hne, Matthias
, p. 4281 - 4285 (2019/08/20)
Imine reductases (IREDs) allow the one-step preparation of optically active secondary and tertiary amines by reductive amination of ketones. Until now, mainly α-chiral amines have been prepared by this route. In this study, we explored the possibility of synthesizing β-chiral amines, a class of compounds which is also frequently found as structural motif in pharmaceuticals but much more challenging to prepare due to the following reasons: (i) The aldehyde substrate already contains the chiral center and needs to be racemized to enable full conversion. (ii) Because the intermediate imine bears the stereo center two carbon atoms remote to the imine nitrogen, it is more challenging to achieve high enantioselectivity compared to α-chiral amine synthesis. For investigating the proof of concept, we first confirmed that different IREDs are able to convert a variety of α-branched aldehydes when combined with five different amine substrates. The IRED from Streptomyces ipomoeae was a suitable enzyme facilitating the dynamic kinetic resolution of 2-phenylpropanal and a substituted 2-methyl-3-phenylpropanal: the corresponding N-methylated β-chiral amines were obtained with '95 % conversion and 78 and 95 %ee. Other amines were formed with low to moderate enantiomeric excess. This exemplifies the potential of IREDs for the one-step synthesis of secondary β-chiral amines, but also the challenge to identify highly selective enzymes for a desired amine product.
