52528-32-2

Basic information

• Product Name: Bicyclo[3.1.1]heptan-2-one, 6,6-dimethyl-3-(phenylmethylene)-
• CAS NO: 52528-32-2
• Molecular Formula: C16H18O
• Molecular Weight: 226.318
• Mol File: 52528-32-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Bicyclo[3.1.1]heptan-2-one, 6,6-dimethyl-3-(phenylmethylene)-(CAS DataBase Reference)
• NIST Chemistry Reference: Bicyclo[3.1.1]heptan-2-one, 6,6-dimethyl-3-(phenylmethylene)-(52528-32-2)
• EPA Substance Registry System: Bicyclo[3.1.1]heptan-2-one, 6,6-dimethyl-3-(phenylmethylene)-(52528-32-2)

Safety Data

• Hazardous Substances Data: 52528-32-2(Hazardous Substances Data)

Upstream product

• 24903-95-5 nopinone 
• 141-52-6 sodium ethanolate 
• 100-52-7 benzaldehyde 
• 18172-67-3 beta-pinene 
• 177698-19-0 Beta-pinene 

Downstream Products

• 95431-86-0 2,6-dibenzylidene-4-(α-chloro-isopropyl)-cyclohexanone 

Relevant articles and documents

Design, synthesis and biological evaluation of novel β-pinene-based thiazole derivatives as potential anticancer agents via mitochondrial-mediated apoptosis pathway

A series of novel β-pinene-based thiazole derivatives were synthesized and characterized by HRMS, 1H NMR, and 13C NMR analyses as potential antineoplastic agents. Derivatives were evaluated for their anticancer activities in vitro, and the data manifested that most target compounds showed potent anti-proliferative activities against three human cancer cell lines. Especially, compound 5g displayed excellent cytotoxic activity against Hela, CT-26, and SMMC-7721 cell lines with IC50 values of 3.48 ± 0.14, 8.84 ± 0.16, and 6.69 ± 0.15 μM, respectively. To determine the underlying mechanism of compound 5g on cell viability, DAPI staining, Annexin-V/PI staining, JC-1 staining, DCFDA staining, and Western blot analysis were performed. Our data showed that compound 5g inhibited cell proliferation by inducing apoptosis and cell cycle arrest of Hela cells at the G0/G1 phase in a dose dependent manner. Further studies revealed that compound 5g enhanced levels of reactive oxygen species (ROS), caused a decrease in mitochondrial membrane potential, increased the release of mitochondrial cytochrome C, and affected the expression of Bax, Bcl-2, caspase-3 and caspase-9. Thus, our findings indicated that compound 5g induced apoptosis in Hela through ROS-mediated mitochondrial dysfunction signaling pathways.

four hydrogens kuikui zuo lin - 2 - amine sheaf alkali compound and its synthetic method and application

The invention discloses tetrahydroquinazoline-2-schiff base compounds as well as a synthesis method and an application thereof. Novel tetrahydroquinazoline-2-schiff base compounds are prepared from a raw material of nopinone which is an oxidative product

Pinanyl pyrazole compound and its synthesis method and use

The invention discloses a pinanyl pyrazole compound and its synthesis method and use. The synthesis method comprises that under action of base catalysis, nopinone and aromatic aldehyde undergo an aldol condensation reaction to produce 3-benzylidenenopinon