52540-15-5

Upstream product

• 100-47-0 benzonitrile 
• 884-90-2 benzyl diethyl phosphate 
• 33611-54-0 2,2-dimethyl-1-phenylpropan-1-imine 
• 938-16-9 2,2-dimethylpropiophenone 
• 611-73-4 Benzoylformic acid 
• 105941-87-5 N’-((2-bromophenyl)-(phenyl)methylene)-4-methylbenzenesulfonohydrazide 
• 3282-30-2 pivaloyl chloride 
• 13047-06-8 o-bromobenzophenone 
• 105941-92-2 C₂₅H₂₆N₂O₃S 

Relevant academic research and scientific papers

Cobalt-Catalyzed, N-H Imine-Directed Arene C-H Benzylation with Benzyl Phosphates

A cobalt-catalyzed ortho-C-H benzylation reaction of pivalophenone N-H imines with benzyl phosphates is reported. The reaction is promoted at room temperature by a ternary catalytic system comprising Co(acac)3, a pyridylphosphine ligand, and a Grignard reagent and tolerates a series of substituted pivalophenone imines and benzyl phosphates to afford various diarylmethane derivatives in moderate yields.

Pd(II)-Catalyzed Direct ortho-C-H Acylation of Aromatic Ketones by Oxidative Decarboxylation of α-Oxocarboxylic Acids

A Pd-catalyzed decarboxylative acylation of aromatic ketones with α-oxocarboxylic acids was developed, and 1,2-diacylbenzenes were formed in up to 90% yield with excellent ortho-selectivity. This work demonstrates the first successful attempt to direct C-H acylation of aromatic ketones without the need for prederivatization to imines. The acylation reaction was inhibited by radical scavengers such as TEMPO, and 2,2,6,6-tetramethylpiperidin-1-yl benzoate, the adduct of TEMPO and a benzoyl radical, has been isolated and characterized. This finding is compatible with the intermediacy of acyl radicals. A mechanism involving the reaction of the palladacyclic complexes of aryl ketones with acyl radicals is proposed.

THE GENERATION AND REACTIONS OF C,N-DIANIONS OF AROMATIC TOSYLHYDRAZONES: ortho-N-DILITHIATED BENZOPHENONE TOSYLHYRAZONE

The ortho, N-dilithiated derivative of the tosylhydrazone of benzophenone (5) has been generated by metal-halogen exchange at low temperature.A range of alkylation, silylation and acylation reactions are described together with further reactions leading to 1,2-diacylbenzenes, phthalazines, 1,3-diphenylisobenzofuran, and a 1,2,3-diazaborine.