5255-66-3

Upstream product

• 64-17-5 ethanol 
• 16001-28-8 N-4-methylphenyl isocyanodichloride 
• 861367-03-5 3-p-tolyl-triazane-1,2-dicarboxylic acid diethyl ester 
• 108-88-3 toluene 
• 64277-81-2 N-p-Tolyl-N-trimethylsilyl-O-ethyl-urethan 
• 5308-12-3 O-ethyl N-(4-methylphenyl)thiocarbamate 
• 201230-82-2 carbon monoxide 
• 106-49-0 p-toluidine 
• 817-87-8 ethyl azidocarbonate 
• 71-43-2 benzene 
• 619-55-6 para-methylbenzamide 
• 134906-71-1 O-ethyl S-(2,4-dinitrophenyl) thiocarbonate 
• 153621-93-3 O-Ethyl S-(2,4,6-trinitrophenyl) thiocarbonate 
• 99-99-0 1-methyl-4-nitrobenzene 

Downstream Products

• 4300-33-8 N-(4-methylphenyl)-N'-phenylurea 
• 622-58-2 p-Tolylisocyanate 
• 90924-49-5 3-p-tolyl-oxazolidine-2,4-dione 
• 129276-09-1 ethyl N-<4-methyl-2-(phthalimidomethyl)phenyl>carbamate 
• 129276-10-4 ethyl N-<4-methyl-3-(phthalimidomethyl)phenyl>carbamate 
• 129276-08-0 ethyl N-<4-methyl-2,5-bis(phthalimidomethyl)phenyl>carbamate 
• 88277-85-4 N,N'-p-tolyl<2.2>paracyclophane-4,5,12,13-tetracarboxylic acid bis-imide 
• 621-00-1 1,3-di-p-tolylurea 
• 100663-77-2 (4-methyl-2-nitro-phenyl)-carbamic acid ethyl ester 
• 100663-78-3 (4-methyl-2,6-dinitro-phenyl)-carbamic acid ethyl ester 
• 109705-16-0 (2-fluoro-4-methylphenyl)urethane 
• 128886-48-6 ((Z)-4-Hydroxy-but-2-enyl)-p-tolyl-carbamic acid ethyl ester 
• 128886-58-8 ((E)-4-Hydroxy-but-2-enyl)-p-tolyl-carbamic acid ethyl ester 
• 128886-69-1 (R)-5-((R)-1,2-Dihydroxy-ethyl)-3-p-tolyl-oxazolidin-2-one 

Relevant academic research and scientific papers

A Mild and Convenient Method for Tritium Labelling of Activated Aromatic Compounds Using BF3-Et2O and Tritiated Water

A procedure for tritium exchange labelling of activated aromatic compounds using 3H2O and BF3-Et2O has been developed to prepare two radio-labelled photoprobes that are difficult to obtain by conventional methods; the applicability of the metho

Synthesis of 4-substituted-1,2-dihydroquinolines by means of gold-catalyzed intramolecular hydroarylation reaction of n-ethoxycarbonyl-n-propargylanilines

An alternative Au(I)-catalyzed synthetic route to functionalized 1,2-dihydroquinolines is reported. This novel approach is based on the use of N-ethoxycarbonyl protected-Npropargylanilines as building blocks that rapidly undergo the IMHA reaction affording the 6-endo cyclization product in good to high yields. In the presence of N-ethoxycarbonyl-N-propargyl-metasubstituted anilines, the regiodivergent cyclization at the ortho-/para-position is achieved by the means of catalyst fine tuning.

Copper-catalyzed carbonylation of anilines by diisopropyl azodicarboxylate for the synthesis of carbamates

A Cu-catalyzed efficient methodology for the direct carbonylation of anilines has been developed. The N-H bond cleavage and N-C bond formation were notably achieved under solvent-free conditions and a variety of carbamates were synthesized from readily available anilines using diisopropyl azodicarboxylate (DIAD) as the carbonylating source.

An efficient one-pot synthesis of: N, N ′-disubstituted ureas and carbamates from N -acylbenzotriazoles

A facile and high-yielding one-pot synthesis of carbamates and N,N′-disubstituted symmetrical ureas from N-acylbenzotriazoles has been devised. It is believed that, the intermediate acyl-azide undergo Curtius rearrangement and in different solvents gives different products i.e. carbamates in alcohols and N,N′-disubstituted symmetrical urea in THF.

One-pot preparation of carbamoyl benzotriazoles and their applications in the preparation of ureas, hydrazinecarboxamides and carbamic esters

Carbamoyl benzotriazoles were conveniently synthesized in one-pot from carboxylic acids, diphenyl phosphorazidate (DPPA) and 1H-benzotriazole (BtH). The reactivity and applications of carbamoyl benzotriazoles were also explored. Carbamoyl benzotriazoles react smoothly with amino acids, hydrazines and alcohols, thus providing facile access to the corresponding ureas, hydrazinecarboxamides and carbamic esters, respectively, in good to excellent yields.

Reaction of organozinc halides with aryl isocyanates

Reformatsky reagent, benzylzinc bromide or alkylzinc iodides react with aryl isocyanates directly to give corresponding N-substituted carbamates under mild reaction conditions. However, the reaction of allylzinc bromide or propargylzinc bromide with aryl isocyanates produces the corresponding N-substituted amides. The reactions provide alternative methods for the synthesis of N-substituted carbamates or amides.

Design and synthesis of novel stiripentol analogues as potential anticonvulsants

A series of stiripentol (STP) analogues namely, 2-[(1E)-1-(1,3-benzodioxol- 5-yl)-4,4-dimethylpent-1-en-3-ylidene]-N-(aryl/H)hydrazinecarboxamides 7a-h, (±)-(5RS)-N-(aryl/H)-(1,3-benzodioxol-5-yl)-3-tert-butyl-4, 5-dihydro-1H-pyrazole-1-carboxamides (±)-8a-h, and (±)-[(5RS)-(1, 3-benzodioxol-5-yl)-3-tert-butyl-4,5-dihydro-1H-pyrazol-1-yl](aryl)methanones (±)-13a-f was synthesized by adopting appropriate synthetic routes and was pharmacologically evaluated in the preliminary anticonvulsant screens. The selected bioactive new chemical entities were subjected to ED50 determination and neurotoxicity evaluation. The most active congeners are 7h in MES screen and (±)-13b in scPTZ screen which displayed ED50 values of 87 and 110 mg/kg, respectively, as compared to that of STP (ED 50 = 277.7 and 115 mg/kg in MES and scPTZ, respectively).

Palladium-catalyzed carbonylation of amines: Switchable approaches to carbamates and N,N′-disubstituted ureas

Switchable access to carbamates and ureas has been developed by solvent control palladium-catalyzed carbonylation of aromatic amines under an atmosphere of carbon monoxide. A variety of N-phenylcarbamates and N,N′- diphenylureas was easily synthesized in good to excellent yields from readily available aromatic amines under mild conditions. Copyright

Dibutyltin oxide catalyzed aminolysis of oxalate to carbamate, oxamate and derivatives of imidazolidine trione

Catalytic aminolysis of oxalates by simple and substituted ureas has been shown to give carbamates, oxamates and derivatives of imidazolidine trione. Various substituted ureas and oxalates were screened to verify the applicability of the protocol. The rol

Synthesis and antibacterial activity of isothiazolyl oxazolidinones and analogous 3(2H)-isothiazolones

The synthesis and antibacterial activity of several new 5-((3-oxoisothiazol-2(3H)-yl)methyl)-3-phenyloxazolidin-2-ones 8 and analogous 2-(4-substituted phenyl)-3(2H)-isothiazolones 3 and 4 substituted at 4 and/or 3-positions of the phenyl moiety with different groups of which some have shown to increase the antibacterial activity of both 3-aryl-2-oxazolidinones and 3(2H)-isothiazolones is described. The most active compounds were isothiazolyl oxazolidinones 8a,j with unsubstituted and 8b with 4-F substituted phenyl rings which showed activities higher than analogous 3(2H)-isothiazolones and comparable or superior to linezolid, vancomycin, and ciprofloxacin against some tested microorganisms. The change in position of F and/or the use of larger substituents gave compounds with reduced or no activity. Evaluation of cytotoxicity to mouse fibroblast (NIH/3T3) cells indicated that these compounds exhibit antibacterial activity at non-cytotoxic concentrations.