5308-12-3

Upstream product

• 64-17-5 ethanol 
• 622-59-3 1-isothiocyanato-4-methylbenzene 
• 3278-38-4 S-phenyl O-ethylxanthate 
• 106-49-0 p-toluidine 
• 19717-02-3 ethyl S-(4-methylphenyl) thiolcarbonate 
• 15151-78-7 ethyl S-(4-chlorophenyl) thiolcarbonate 
• 99358-06-2 S-nitrophenyl O-ethylxanthate 
• 621-01-2 N,N'-Bis(p-tolyl)thiourea 
• 3278-35-1 S-(ethoxycarbonyl) O-ethyl dithiocarbonate 

Downstream Products

• 1145-66-0 1-(4-methylphenyl)-3-phenylthiourea 
• 5255-66-3 ethyl p-tolylcarbamate 
• 622-58-2 p-Tolylisocyanate 

Relevant academic research and scientific papers

Pathogenic Gram-positive bacteria are highly sensitive to triphenylphosphanegold(O-alkylthiocarbamates), Ph3PAu[SC(OR)=N(p- tolyl)] (R = Me, et and iPr)

The phosphanegold(I) thiocarbamides, Ph3PAu{SC(OR)=NC 6H4Me-4} for R = Me (1), Et (2) and iPr (3), have been shown to have essentially linear gold atom coordination geometries defined by phosphane-P and thiolate-S atoms, and exhibit minimum inhibitory concentration (MIC) values in the range of 1-37 μg/ml against four Gram-positive bacteria, namely Bacillus cereus, Enterococcus faecalis, Enterococcus faecium and Staphylococcus aureus; compounds 1-3 are less potent against a broad panel of 16 Gram-negative bacteria. As the minimum bactericidal concentration values were quite similar to the MIC values, compounds 1-3 are effective bactericidal agents. The specific action against the four Gram-positive bacteria suggests they function by inhibition of peptidoglycan synthesis.

Syntheses of N-alkyl, A,N-dialkyl, and N-(4-substituted phenyl) O-ethyl thioncarbamates: A kinetic study

The kinetics of the syntheses of N-alkyl, N,N-dialkyl, and N-(4-substituted phenyl) O-ethyl thioncarbamates from sodium ethyl xanthogenacetate, ten alkylamines, and eight substituted anilines were studied at 25, 30, 35, and 40 °C. The reactions were found to follow second-order kinetics. The kinetic (Arrhenius) parameters, such as the activation energy and the frequency factor, as well as the Eyring parameters, such as the standard entropy, the standard Gibbs energy, and the standard enthalpy of activation, were calculated from the second-order rate constants. The mechanism of the reaction was postulated based on the kinetic studies presented and the optimization of the reaction mechanism using the MOPAC PM6 semi-empirical method.

3,4-diarylthiazolin-2-one or -2-thione derivatives, their methods of preparation and their uses in their methods of preparation and their uses in therapeutics

The present invention relates to derivatives of formula STR1 and to their use in therapeutics especially as drugs with anti-inflammatory and analgesic properties.

Kinetics and mechanism of the aminolysis of O-ethyl S-aryl dithiocarbonates in acetonitrile

The aminolysis reactions of O-ethyl S-(Z-phenyl) dithiocarbonates (Z = p-CH3, H, p-Cl, and p-NO2) with anilines (AN) and N,N-dimethylanilines (DMA) in acetonitrile at 30.0 °C are investigated. Relatively small values of βx (βnuc, 0.4 ca. 0.7) and βz (βlg-0.1 ca. -0.4) for both ANs and DMAs, significantly large kH/kD values (1.1 ca. 1.9) involving deuterated anilines, and large negative ρxz values for ANs (-0.56) are interpreted to indicate a concerted mechanism for both ANs and DMAs but with a hydrogen bonded four-center type transition state (TS) for ANs. The relative leaving ability, k(Z = p-NO2)/k(Z = p-CH3), is smaller for ANs than for DMAs, especially for a weaker nucleophile (1.9 and 4.7 for AN and DMA, respectively, with X = p-Cl). This suggests that the rate enhancement by the hydrogen-bond formation in the four-center type TS for AN is greater for a weaker nucleofuge (Z = p-CH3), especially when the nucleophile (X = p-Cl) is weaker.