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Usage

Uses

Used in Organic Synthesis:
Acetamide, N-[1-(4-methylphenyl)-2-propynyl](9CI) is utilized as a building block in the synthesis of complex organic molecules, leveraging its unique molecular structure to facilitate the creation of a variety of chemical compounds.
Used in Pharmaceutical Production:
Acetamide, N-[1-(4-methylphenyl)-2-propynyl] (9CI) serves as a precursor in the pharmaceutical industry, potentially contributing to the development of new drugs by providing a foundational structure that can be further modified and optimized for specific therapeutic applications.
Used in Agrochemical Production:
Acetamide, N-[1-(4-methylphenyl)-2-propynyl](9CI) is employed in the agrochemical sector as a starting material for the synthesis of various agrochemicals, such as pesticides and herbicides, due to its potential to be incorporated into their molecular structures.
Further research is necessary to fully understand the properties and explore the complete spectrum of applications for Acetamide, N-[1-(4-methylphenyl)-2-propynyl](9CI), as its current known uses are based on its potential in these areas.

Upstream product

• 60-35-5 acetamide 
• 132589-36-7 1-(4-methylphenyl)prop-2-yn-1-ol 
• 75-05-8 acetonitrile 

Downstream Products

• 1350538-90-7 5-(5-chloro-2-(furan-2-yl)-1H-indol-3-yl)-2-methyl-4-p-tolyloxazole 
• 1350538-92-9 5-(5-chloro-2-(3-chlorophenyl)-1H-indol-3-yl)-2-methyl-4-p-tolyloxazole 
• 1350538-87-2 5-(5-chloro-2-(4-chlorophenyl)-1H-indol-3-yl)-2-methyl-4-p-tolyloxazole 
• 1350538-84-9 5-(5-chloro-2-p-tolyl-1H-indol-3-yl)-2-methyl-4-p-tolyloxazole 
• 1350538-83-8 2-methyl-5-(5-methyl-2-(thiophen-2-yl)-1H-indol-3-yl)-4-p-tolyloxazole 
• 1350538-80-5 2-methyl-5-(5-methyl-2-phenyl-1H-indol-3-yl)-4-p-tolyloxazole 
• 1350538-78-1 2-methyl-5-(5-methyl-2-p-tolyl-1H-indol-3-yl)-4-p-tolyloxazole 
• 1350538-76-9 5-(2-(4-chlorophenyl)-5-methyl-1H-indol-3-yl)-2-methyl-4-p-tolyloxazole 
• 1350538-73-6 2-methyl-5-(2-phenyl-1H-indol-3-yl)-4-p-tolyloxazole 
• 1350538-72-5 5-(2-(4-chlorophenyl)-1H-indol-3-yl)-2-methyl-4-p-tolyloxazole 
• 1350538-71-4 2-methyl-4-p-tolyl-5-(2-p-tolyl-1H-indol-3-yl)oxazole 

Relevant academic research and scientific papers

Silver-Catalyzed Synthesis of Substituted Pyridine Derivatives from N-Propargylic α-Enamino Esters

A wide range of substituted pyridine derivatives were synthesized in moderate to good yields from N-propargylic α-enamino esters. The synthetic strategy involved regioselective addition of a propargylamine to the α-carbon atom of an alkynyl ester to produce the N-propargylic α-enamino ester, which acted as the key intermediate in the synthesis.

Ruthenium-catalyzed propargylic substitution reactions of propargylic alcohols with oxygen-, nitrogen-, and phosphorus-centered nucleophiles

The scope and limitations of the ruthenium-catalyzed propargylic substitution reaction of propargylic alcohols with heteroatom-centered nucleophiles are presented. Oxygen-, nitrogen-, and phosphorus-centered nucleophiles such as alcohols, amines, amides, and phosphine oxide are available for this catalytic reaction. Only the thiolate-bridged diruthenium complexes can work as catalysts for this reaction. Results of some stoichiometric and catalytic reactions indicate that the catalytic propargylic substitution reaction proceeds via an allenylidene complex formed in situ, whereby the attack of nucleophiles to the allenylidene Cγ atom is a key step. Investigation of the relative rate constants for the reaction of propargylic alcohols with several para-substituted anilines reveals that the attack of anilines on the allenylidene Cγ atom is not involved in the rate-determining step and rather the acidity of conjugated anilines of an alkynyl complex, which is formed after the attack of aniline on the C γ atom, is considered to be the most important factor to determine the rate of this catalytic reaction. The key point to promote this catalytic reaction by using the thiolate-bridged diruthenium complexes is considered to be the ease of the ligand exchange step between a vinylidene ligand on the diruthenium complexes and another propargylic alcohol in the catalytic cycle. The reason why only the thiolate-bridged diruthenium complexes promote the ligand exchange step more easily with respect to other monoruthenium complexes in this catalytic reaction should be that one Ru moiety, which is not involved in the allenylidene formation, works as an electron pool or a mobile ligand to another Ru site. The catalytic procedure presented here provides a versatile, direct, and one-step method for propargylic substitution of propargylic alcohols in contrast to the so far well-known stoichiometric and stepwise Nicholas reaction.

Enantioselective synthesis of 1-aryl-2-propenylamines: A new approach to a stereoselective synthesis of the Taxol side chain

A variety of substituted 1-aryl-2-propenylamines of high enantiomeric purity were prepared via lipase-catalysed resolution of the corresponding racemates. (R)-1-Phenyl-2-propenylamine was further synthesised into (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoic acid methyl ester, the side chain of Taxol.