526217-60-7

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 130697-96-0 methyl amino(3-hydroxyphenyl)acetate 
• 31932-87-3 D-α-amino-m-hydroxyphenylacetic acid 

Downstream Products

• 1454273-67-6 tert-butyl (2-hydroxy-1-(3-hydroxyphenyl)ethyl)carbamate 
• 913523-95-2 tert-butyl (1-(3-(benzyloxy)phenyl)-2-hydroxyethyl)carbamate 
• 1454273-68-7 2-(3-(benzyloxy)phenyl)-2-((tert-butoxycarbonyl)amino)ethyl methanesulfonate 
• 1043499-24-6 (RS)-tert-butoxycarbonylamino-[3-(tetrahydropyran-4-yloxy)phenyl]acetic acid methyl ester 
• 130426-41-4 (CO)3Mn(C₆H₃(CH₃O)(CH₃)OC₆H₄CH(CO₂CH₃)(NHC(O)OC(CH₃)3))⁽¹⁺⁾*PF₆^(1-) = (MnC₂₅H₂₇NO₉)(PF₆) 
• 526217-37-8 N-[2-hydroxy-1-(3-methoxyphenyl)-2-methylpropyl]octanamide 
• 526217-36-7 tert-butyl 2-hydroxy-1-(3-methoxyphenyl)-2-methylpropylcarbamate 
• 526217-35-6 methyl 2-(tert-butoxycarbonylamino)-2-(3-methoxyphenyl)acetate 

Relevant academic research and scientific papers

GONADOTROPIN RELEASING HORMONE RECEPTOR ANTAGONISTS, METHOD FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

Disclosed are a gonadotropin releasing hormone receptor antagonist and a pharmaceutical composition including the same, which can be useful in preventing or treating a sex hormone-related disease such as endometriosis, amenorrhea, irregular menstruation, uterine myoma, uterine fibroids, polycystic ovarian disease, lupus erythematous, hypertrichosis, precocious puberty, short stature, acne, alopecia, gonadal steroid-dependent neoplasms, gonadotropin-producing pituitary adenoma, sleep apnea, irritable bowel syndrome, premenstrual syndrome, benign prostatic hyperplasia, contraception, and infertility, as well as Alzheimer disease.

GONADOTROPIN RELEASING HORMONE RECEPTOR ANTAGONISTS, METHOD FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

The present invention provides gonadotropin releasing hormone receptor antagonists and the pharmaceutical composition comprising the same, which can be useful in preventing or treating a sex hormone-related disease such as endometriosis, amenorrhea, irregular menstruation, uterine myoma, uterine fibroids, polycystic ovarian disease, lupus erythematous, hypertrichosis, precocious puberty, short stature, acne, alopecia, gonadal steroid-dependent neoplasms, gonadotropin-producing pituitary adenoma, sleep apnea, irritable bowel syndrome, premenstrual syndrome, benign prostatic hyperplasia, contraception, and infertility, as well as Alzheimer disease

Highly potent inhibitors of TNF-α production. Part II: Metabolic stabilization of a newly found chemical lead and conformational analysis of an active diastereoisomer

Design and synthesis of metabolically stabilized inhibitors of TNF-α production, which could be new drug candidates, are reported. Conformational analysis of an active diastereoisomer was performed based on biological evaluations of the conformationally f