52634-39-6

Upstream product

• 4070-48-8 L-Valine methyl ester 
• 6968-11-2 N,N'-bis(benzyloxycarbonyl)-L-cystine 
• 52634-47-6 (S)-2-((R)-4-Benzyloxycarbonylamino-3-oxo-isothiazolidin-2-yl)-3-methyl-butyric acid methyl ester 

Downstream Products

• 6776-41-6 N-Benzyloxycarbonyl-L-cysteinyl-L-valin-methylester 
• 52634-47-6 (S)-2-((R)-4-Benzyloxycarbonylamino-3-oxo-isothiazolidin-2-yl)-3-methyl-butyric acid methyl ester 

Relevant academic research and scientific papers

Reactivity, Selectivity, and Stability in Sulfenic Acid Detection: A Comparative Study of Nucleophilic and Electrophilic Probes

The comparative reaction efficiencies of currently used nucleophilic and electrophilic probes toward cysteine sulfenic acid have been thoroughly evaluated in two different settings-(i) a small molecule dipeptide based model and (ii) a recombinant protein model. We further evaluated the stability of corresponding thioether and sulfoxide adducts under reducing conditions which are commonly encountered during proteomic protocols and in cell analysis. Powered by the development of new cyclic and linear C-nucleophiles, the unsurpassed efficiency in the capture of sulfenic acid under competitive conditions is achieved and thus holds great promise as highly potent tools for activity-based sulfenome profiling.