52670-78-7

Basic information

• Product Name: diethyl methyl(phenyl)amidophosphate
• CAS NO: 52670-78-7
• Molecular Formula: C₁₁H₁₈NO₃P
• Molecular Weight: 243.2393
• Mol File: 52670-78-7.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 297.4°C at 760 mmHg
• Flash Point: 133.6°C
• Density: 1.137g/cm³
• Vapor Pressure: 0.00136mmHg at 25°C
• Refractive Index: 1.518
• CAS DataBase Reference: diethyl methyl(phenyl)amidophosphate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl methyl(phenyl)amidophosphate(52670-78-7)
• EPA Substance Registry System: diethyl methyl(phenyl)amidophosphate(52670-78-7)

Safety Data

• Hazardous Substances Data: 52670-78-7(Hazardous Substances Data)

Upstream product

• 64-17-5 ethanol 
• 2503-67-5 methyl-phenyl-amidophosphoryl chloride 
• 141-52-6 sodium ethanolate 
• 762-04-9 phosphonic acid diethyl ester 
• 100-61-8 N-methylaniline 
• 814-49-3 diethyl chlorophosphate 
• 74-88-4 methyl iodide 
• 122-52-1 triethyl phosphite 
• 2397-47-9 triethyl N-phenylphosphorimidate 

Downstream Products

• 115384-36-6 diethyl <2-(methylamino)phenyl>phosphonate 

Relevant articles and documents

Electrochemical phosphorylation of arenols and anilines leading to organophosphates and phosphoramidates

A practical phosphorylation for generating organophosphates and phosphoramidatesviaelectrochemical dehydrogenative cross-coupling of P(O)H compounds with arenols and anilines is disclosed. This method involves using inorganic iodide salts as both redox catalysts and electrolytes in an undivided cell without the addition of oxidants or bases. A preliminary mechanistic study suggests that radicals are not involved in this process. This method is green and eco-friendly and has good functional group tolerance, high yields and broad substrate scope, with the potential for practical synthesis.

Fe3O4@MgO nanoparticles as an efficient recyclable catalyst for the synthesis of phosphoroamidates via the Atherton-Todd reaction Dedicated to Professor Tsutomu Yokomatsu from Tokyo University of Pharmacy and Life Sciences on the occasion of his 65th birthday

A simple and efficient method is presented for the synthesis of phosphoroamidates in moderate to good yield via the Atherton-Todd coupling of primary amines with H-dialkyl phosphites using Fe3O4@MgO nanoparticles as a recyclable catalyst.

Cross-hetero-dehydrogenative coupling reaction of phosphites: A catalytic metal-free phosphorylation of amines and alcohols

Phosphorylation of amines, alcohols, and sulfoximines are accomplished using molecular iodine as a catalyst and H2O2 as the sole oxidant under mild reaction conditions. This method provides an easy route for synthesizing a variety of phosphoramidates, phosphorus triesters and sulfoximine-derived phosphoramidates which are of biological importance.