52687-98-6Relevant articles and documents
Synthesis and antimicrobial activities of structurally novel S,S′-bis(heterosubstituted) disulfides
Ramaraju, Praveen,Gergeres, Danielle,Turos, Edward,Dickey, Sonja,Lim, Daniel V.,Thomas, John,Anderson, Burt
experimental part, p. 3623 - 3631 (2012/07/16)
The central focus of this study is on the antibacterial and antifungal properties of synthetically produced S,S′-bis(heterosubstituted) disulfides as a means to control the growth of various infection-causing pathogens. Staphylococcus aureus, Francisella tularensis and Candida albicans were each found to be highly susceptible to several of these compounds by agar or broth dilution and Kirby-Bauer diffusion assays. These structurally simple, low molecular weight disulfides have shown promising bioactivities and may serve as leads to the development of effective new antibacterials for pathogenic bacteria such as methicillin-resistant S. aureus and F. tularensis.
Substituent effects on the reactivity of benzo-1,2-dithiolan-3-one 1-oxides and their possible application to the synthesis of DNA-targeting drugs
Sawwan, Nahed,Brzostowska, Edyta M.,Greer, Alexander
, p. 6968 - 6971 (2007/10/03)
The efficiency of polysulfane product generation has been investigated for n-propyl thiol reactions with ortho- and para-substituted benzo-1,2-dithiolan-3- one 1-oxides in acetonitrile-water (7:3) mixtures. The reaction is facilitated by reducing the electron density at the para position or by placing substituents bearing lone pair electrons ortho to the dithiolanone-oxide (S1) reaction center. Through-space and through-bond effects both contribute to the conversion of polysulfane products.
Formation of dialkyl polysulfides from vinyl ethers in the system H2S-DMSO-MOH
Musorin,Sedunova,Trofimov
, p. 794 - 797 (2007/10/03)
The reaction of vinyl ethers with the system H2S-DMSO-MOH (30°C, 5 h) gives dialkyl polysulfides with a total yield of up to 65% instead of expected oxygen-containing thiols and sulfides. The ratio between dialkyl di-, tri-, and tetrasulfides depends on the nature of the vinyl ether and on the amount of alkali metal hydroxide in the reaction mixture. With di(propen-1-yl) ether, 4-methyl-2-ethyl-1,3-oxathiolane was also found as a by-product.