52708-34-6

Usage

Uses

Used in Organic Synthesis:
Benzenamine, 4-(2H-1,2,3-triazol-2-yl)is used as a key intermediate in the synthesis of 1,2,3-triazole derivatives for their diverse applications in pharmaceuticals, agrochemicals, and materials science.
Used in Pharmaceutical Industry:
Benzenamine, 4-(2H-1,2,3-triazol-2-yl)is used as a building block for the development of new pharmaceutical compounds, given its potential in forming 1,2,3-triazole derivatives with various biological activities.
Used in Agrochemical Industry:
Benzenamine, 4-(2H-1,2,3-triazol-2-yl)is used as a component in the creation of agrochemicals, such as pesticides and herbicides, due to the versatility of 1,2,3-triazole derivatives in these applications.
Used in Materials Science:
Benzenamine, 4-(2H-1,2,3-triazol-2-yl)is used in the development of new materials with specific properties, leveraging the unique characteristics of 1,2,3-triazole derivatives.
Used in Antifungal and Antibacterial Applications:
Benzenamine, 4-(2H-1,2,3-triazol-2-yl)is studied for its potential antifungal and antibacterial properties, which could lead to its use in medical and environmental applications for controlling microbial growth.

Upstream product

• 18922-72-0 2-(4-nitrophenyl)-2H-1,2,3-triazole 
• 51039-49-7 2-phenyl-2H-[1,2,3]triazole 
• 1192847-37-2 C₈H₃Br₃N₄O₂ 
• 288-36-8 1,2,3-triazole 
• 350-46-9 4-Fluoronitrobenzene 
• 106-40-1 4-bromo-aniline 
• 288-36-8 1 ,2,3-Triazole 
• 1534-21-0 glyoxal bis(phenylhydrazone) 

Downstream Products

• 1403818-81-4 N-(4-(2H-1,2,3-triazol-2-yl)phenyl)-5-(thiophen-2-yl)-1H-pyrazolo[4,3-d]pyrimidin-7-amine 
• 170862-72-3 6-(2H-1,2,3-triazol-2-yl)benzo[d]thiazol-2-amine 
• 181869-25-0 1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(2H-1,2,3-triazol-2-yl)phenyl]-2(1H,3H)-imidazolone 
• 181870-04-2 1-(2,2-diethoxy-ethyl)-3-(4-[1,2,3]triazol-2-yl-phenyl)-urea 
• 181869-84-1 C₉H₁₀N₆O 
• 181870-10-0 1-[4-(2H-1,2,3-triazol-2-yl)phenyl]-2(1H,3H)-imidazolone 
• 181869-76-1 (4-[1,2,3]triazol-2-yl-phenyl)-carbamic acid phenyl ester 
• 855934-92-8 N-acetyl-sulfanilic acid-(4-[1,2,3]triazol-2-yl-anilide) 

Relevant academic research and scientific papers

Copper nanoparticles (CuNPs) catalyzed chemoselective reduction of nitroarenes in aqueous medium

Abstract: A procedure for practical synthesis of CuNPs from CuSO4·5H2O is established, under appropriate reaction conditions, using rice (Oryza sativa) as an economic source of reducing as well as a stabilizing agent. Optical and microscopic techniques are employed for the characterization of the synthesized CuNPs and the sizes of the particles were found to be in the range of 8 ± 2 nm. The nanoparticles are used as a catalyst for chemoselective reduction of aromatic nitro compounds to corresponding amines under ambient conditions and water as a reaction medium. Graphic abstract: CuNPs are synthesized using hydrolysed rice and used as catalyst for chemoselective reduction of nitroarenes to their corresponding amines in water. [Figure not available: see fulltext.]

NOVEL COMPOUNDS

The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase L1 (UCHL1). The invention further relates to the use of DUB inhibitors in the treatment of cancer and other indications. Compounds of the invention include compounds having the formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 to R8 are as defined herein.

HEPARAN SULFATE BIOSYNTHESIS INHIBITORS FOR THE TREATMENT OF DISEASES

Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions in need of inhibition of heparan sulfate biosynthesis.

PYRROLO AND PYRAZOLOPYRIMIDINES AS UBIQUITIN-SPECIFIC PROTEASE 7 INHIBITORS

The invention relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where m, n, X1, X2, R1-R5, R5′ and R6 are described herein.

IMINOSUGARS USEFUL FOR THE TREATMENT OF VIRAL DISEASES

Formula IA, ad their use for treating viral infections.

HIV PROTEASE INHIBITORS

Compounds of Formula I are disclosed: wherein A, R1, R2, R3, R4A, R4B, R5, R6 and R7 are defined herein. The compounds encompassed by Formula I include compounds which

Highly regioselective N-2 arylation of 4,5-dibromo-1,2,3-triazole: efficient synthesis of 2-aryltriazoles

Reaction of 4,5-dibromo-1,2,3-triazole with electron-deficient aromatic halides in the presence of potassium carbonate in DMF produces the corresponding 2-aryl-4,5-dibromotriazoles with high regioselectivity. Subsequent debromination of these triazoles by

Amide thiadiazole inhibitors of plasminogen activator inhibitor-1

Methods of treating disorders associated with elevated levels of PAI-1 are disclosed comprising administering to a patient in need thereof a therapeutically effective amount of at least one compound of formula at least one compound of formula (I), or a ph

1-(2-Naphthyl)-1H-pyrazole-5-carboxylamides as potent factor Xa inhibitors. Part 2: A survey of P4 motifs

A variety of P4 motifs have been examined to increase the binding affinity and in vitro anticoagulant potency of our biphenyl 1-(2-naphthyl)-1H-pyrazole-5- carboxylamide-based fXa inhibitors. Highly potent 2-naphthyl-P1 fXa inhibitors (Ki≤2 nM) with improved in vitro anticoagulant activity (2×TG≤1 μM) and respectable pharmacokinetic properties have been discovered.

Azole antifungal agents, processes for the preparation thereof, and intermediates

A compound represented by the general formula: wherein R1 and R2 denote a halogen atom or hydrogen atoms; R3 means a hydrogen atoms or lower alkyl group; r and m stand for 0 or 1; A is N or CH; W denotes an aromatic ring or a condensed ring thereof; X means another aromatic rings, an alkanediyl group, an alkenediyl group, or an alkynediyl group; Y stand for -S-, etc.; Z denotes a hydrogen atom, etc., or a salt thereof, and intermediates thereof or a salt thereof as well as processes for the preparation thereof, and pharmacetical composition suitable for use as an antifungal agent.