1008-95-3

Basic information

• Product Name: 4-(1,3-OXAZOL-5-YL)ANILINE
• Synonyms: 4-(5-Oxazolyl)aniline;4-(oxazol-5-yl)aniline;4-(1,3-Oxazol-5-yl);4-(1,3-OXAZOL-5-YL)ANILINE;5-(4-AMINOPHENYL)OXAZOLE;4-(1,3-Oxazol-5-yl)aniline, tech
• CAS NO: 1008-95-3
• Molecular Formula: C₉H₈N₂O
• Molecular Weight: 160.17
• Product Categories: Phenyls & Phenyl-Het;Phenyls & Phenyl-Het;Amines and Anilines;Heterocycles;Amines
• Mol File: 1008-95-3.mol
• Article Data: 12

Chemical Properties

• Melting Point: 150 °C
• Boiling Point: 318.7 °C at 760 mmHg
• Flash Point: 146.5 °C
• Appearance: /
• Density: 1.204 g/cm³
• Vapor Pressure: 0.000356mmHg at 25°C
• Refractive Index: 1.599
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 3.46±0.10(Predicted)
• CAS DataBase Reference: 4-(1,3-OXAZOL-5-YL)ANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(1,3-OXAZOL-5-YL)ANILINE(1008-95-3)
• EPA Substance Registry System: 4-(1,3-OXAZOL-5-YL)ANILINE(1008-95-3)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-36-22
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 1008-95-3(Hazardous Substances Data)

Usage

General Description

4-(1,3-oxazol-5-yl)aniline, also known as 5-(4-aminophenyl)-1,3-oxazole, is a chemical compound with the molecular formula C9H8N2O. It is a heterocyclic compound that contains both an aniline and an oxazole moiety. The compound is commonly used in medicinal and pharmaceutical research, as well as in organic synthesis. It has been studied for its potential as a building block in the synthesis of bioactive compounds and as a potential inhibitor of certain enzymes. Additionally, 4-(1,3-oxazol-5-yl)aniline has been found to exhibit antimicrobial and anti-inflammatory properties, making it a subject of interest for further exploration in drug development and disease treatment.

InChI:InChI=1/C9H8N2O/c10-8-3-1-7(2-4-8)9-5-11-6-12-9/h1-6H,10H2

Upstream product

• 38622-91-2 [(p-methylphenyl)sulfonylmethyl]isonitrile 
• 555-16-8 4-nitrobenzaldehdye 
• 1014-23-9 5-(4-nitrophenyl)oxazole 
• 7439-89-6 iron 
• 470715-98-1 acetic acid acetoxy-(2-bromo-4-nitro-phenyl)-methyl ester 
• 5274-71-5 2-bromo-4-nitro-benzaldehyde 
• 267648-15-7 5-(2-bromo-4-nitrophenyl)oxazole 
• 7745-93-9 2-bromo-4-nitrotoluene 
• 1186127-11-6 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(triisopropylsilyl)-1,3-oxazole 

Downstream Products

• 333728-92-0 C₁₉H₁₃N₇O₂ 
• 738570-45-1 (4-oxazol-5-yl-phenyl)-hydrazine 
• 774239-16-6 4-(oxazol-5-yl)benzenediazonium tetrafluoroborate 
• 1610874-78-6 2-(2-chlorophenyl)-N-(4-(oxazol-5-yl)phenyl)acetamide 

Relevant articles and documents

Discovery of a Potent Glutathione Peroxidase 4 Inhibitor as a Selective Ferroptosis Inducer

Potent and selective ferroptosis regulators promote an intensive understanding of the regulation and mechanisms underlying ferroptosis, which is highly associated with various diseases. In this study, through a stepwise structure optimization, a potent and selective ferroptosis inducer was developed targeting to inhibit glutathione peroxidase 4 (GPX4), and the structure-activity relationship (SAR) of these compounds was uncovered. Compound26aexhibited outstanding GPX4 inhibitory activity with a percent inhibition up to 71.7% at 1.0 μM compared to 45.9% of RSL-3. At the cellular level,26acould significantly induce lipid peroxide (LPO) increase and effectively induce ferroptosis with satisfactory selectivity (the value of 31.5). The morphological analysis confirmed the ferroptosis induced by26a. Furthermore,26asignificantly restrained tumor growth in a mouse 4T1 xenograft model without obvious toxicity.

Method for preparing amine through catalytic reduction of nitro compound by cyclic (alkyl) (amino) carbene chromium complex

The cyclic (alkyl) (amino) carbene chromium complex is prepared from corresponding ligand salt, alkali and CrCl3 and used for catalyzing pinacol borane to reduce nitro compounds in an ether solvent under mild conditions to generate corresponding amine. The method for preparing amine has the advantages of cheap and accessible raw materials, mild reaction conditions, wide substrate application range, high selectivity and the like, and is simple to operate.

HETEROARYL RHEB INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same. Compositions comprising a compound of this invention or a pharmaceutically acceptable derivative thereof and a pharmaceutically acceptable carrier, adjuvant, or vehicle. The amount of the compound in compositions of this invention is such that it is effective to measurably inhibit Rheb, in a biological sample or in a patient.