186390-79-4

Basic information

• Product Name: tert-butyl6-nitro-3,4-dihydroisoquinoline-2(1H)-carboxylate
• Synonyms: 2(1H)-Isoquinolinecarboxylic acid, 3,4-dihydro-6-nitro-, 1,1-dimethylethyl ester
• CAS NO: 186390-79-4
• Molecular Formula: C14H18N2O4
• Molecular Weight: 278.30372
• Mol File: 186390-79-4.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 400.0±45.0 °C(Predicted)
• Appearance: /
• Density: 1.229±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: -1.69±0.20(Predicted)
• CAS DataBase Reference: tert-butyl6-nitro-3,4-dihydroisoquinoline-2(1H)-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl6-nitro-3,4-dihydroisoquinoline-2(1H)-carboxylate(186390-79-4)
• EPA Substance Registry System: tert-butyl6-nitro-3,4-dihydroisoquinoline-2(1H)-carboxylate(186390-79-4)

Safety Data

• Hazardous Substances Data: 186390-79-4(Hazardous Substances Data)

Usage

General Description

Tert-butyl 6-nitro-3,4-dihydroisoquinoline-2(1H)-carboxylate is a chemical compound with a complex, multi-part name. It is a nitro-substituted dihydroisoquinoline derivative with a tert-butyl ester group and a carboxylate functional group. tert-butyl6-nitro-3,4-dihydroisoquinoline-2(1H)-carboxylate is potentially useful in pharmaceutical and chemical industries due to its unique molecular structure, which could make it a valuable building block for the synthesis of new drugs or materials. Additionally, the tert-butyl group can provide steric hindrance and may influence the compound's reactivity and specific properties. Overall, tert-butyl 6-nitro-3,4-dihydroisoquinoline-2(1H)-carboxylate represents a potentially important and versatile compound with various potential applications in research and industry.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 144-55-8 sodium hydrogencarbonate 
• 186390-77-2 6-nitro-1,2,3,4-tetrahydro-isoquinoline 
• 5274-71-5 2-bromo-4-nitro-benzaldehyde 
• 55649-51-9 2-(trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline 
• 458-85-5 2,2,2-trifluoro-N-(2-phenylethyl)acetamide 
• 64-04-0 phenethylamine 
• 14026-45-0 6-nitro-1,2,3,4-tetrahydroquinoline 

Downstream Products

• 164148-92-9 tert-butyl 6-amino-3,4-dihydroisoquinoline-2(1H)-carboxylate 

Relevant articles and documents

Lithioarene Cycliacylation and Pd-Catalyzed Aminoethylation/Cyclization to Access Electronically Diverse Saturated Isoquinoline Derivatives

We report operationally facile methods for the synthesis of substituted dihydroisoquinolinones and tetrahydroisoquinolines from readily accessible o-bromobenzyl bromides and o-bromobenzaldehydes, respectively. While classical electrophilic aromatic substitution reactions are tailored to the construction of saturated isoquinolines derived from electron-rich precursors, we demonstrate efficient syntheses from electronically diverse substrates to produce cyclized products as single regioisomers.

SUBSTITUTED IMIDAZO[1,5-A]PYRIMIDINES AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS

The invention provides substituted imidazo[1,5-a]pyrimidines and related organic compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat medical disorders, e.g., Gaucher disease, Parkinson's disease, Lewy body disease, dementia, or multiple system atrophy, in a patient. Exemplary substituted imidazo[1,5-a]pyrimidine compounds described herein include substituted 2,4-dimethyl-N-phenylimidazo[1,5-a]pyrimidine-8-carboxamide compounds and variants thereof.

Biphenyl-2-carboxylic acid-tetrahydro-isoquinolin-6-yl amide derivatives, their preparation and use as inhibitors of microsomal triglyceride transfer protein and/or apolipoprotein B (ApoB) secretion

Compositions comprising a lipid lowering agent selected from cholesterol biosynthesis inhibitors, bile acid sequestrants, fibrates, cholesterol absorption inhibitors, and niacin; and an inhibitor of microsomal triglyceride transfer protein for treating atherosclerosis, obesity and related diseases.