5276-63-1

Basic information

• Product Name: N-(2,4-dichloro-5-{[(Z)-(6-oxo-5-prop-2-en-1-ylcyclohexa-2,4-dien-1-ylidene)methyl]amino}phenyl)acetamide
• CAS NO: 5276-63-1
• Molecular Formula: C₂₈H₃₀N₂O₅
• Molecular Weight: 363.2378
• Mol File: 5276-63-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 537.9°C at 760 mmHg
• Flash Point: 279.1°C
• Density: 1.406g/cm³
• Vapor Pressure: 1.22E-11mmHg at 25°C
• Refractive Index: 1.703
• CAS DataBase Reference: N-(2,4-dichloro-5-{[(Z)-(6-oxo-5-prop-2-en-1-ylcyclohexa-2,4-dien-1-ylidene)methyl]amino}phenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2,4-dichloro-5-{[(Z)-(6-oxo-5-prop-2-en-1-ylcyclohexa-2,4-dien-1-ylidene)methyl]amino}phenyl)acetamide(5276-63-1)
• EPA Substance Registry System: N-(2,4-dichloro-5-{[(Z)-(6-oxo-5-prop-2-en-1-ylcyclohexa-2,4-dien-1-ylidene)methyl]amino}phenyl)acetamide(5276-63-1)

Safety Data

• Hazardous Substances Data: 5276-63-1(Hazardous Substances Data)

Upstream product

• 1161-13-3 N-Cbz-L-Phe 
• 1059596-58-5 N-Cbz-L-phenylalanine p-tolylthiol ester 
• 3081-24-1 H-Phe-OEt 
• 3272-95-5 Z-L-Phe p-chlorophenyl ester 
• 3182-93-2 (L)-phenylalanine ethyl ester hydrochloride 
• 3085-87-8 Benzyloxycarbonyl-phenylalanin-<3>-pyridylester 
• 52641-32-4 N-benzyloxycarbonyl-L-phenylalanyl chloride 
• 541-41-3 chloroformic acid ethyl ester 
• 3588-57-6 Z-DL-Phe-OH 
• 21887-86-5 benzyl (1-hydrazinyl-1-oxo-3-phenylpropan-2-yl)carbamate 

Downstream Products

• 67247-04-5 Phe-Phe-OEt 
• 141056-54-4 N-benzyloxycarbonyl-L-phenylalanyl-L-phenylalaninamide 
• 106454-50-6 N-(N-benzyloxycarbonyl-phenylalanyl)-phenylalanine 

Relevant articles and documents

HMDO-promoted peptide and protein synthesis in ionic liquids

Hexamethyldisiloxane (HMDO) has been developed to efficiently promote the metal-free direct coupling of an amino function of one cysteine-free peptide or protein and a C-terminal thioester of the second peptide in ionic liquids. The amide-coupling reaction proceeds smoothly under mild conditions to afford the corresponding products in good to excellent yields (63-94%). Peptide couplings were also achieved using in-situ-generated thioesters by the thioesterification of oxo esters.

High isolated yields in thermodynamically controlled peptide synthesis in toluene catalysed by thermolysin adsorbed on Celite R-640

An innovative immobilisation method that allows peptide synthesis to be performed even at equimolar concentrations, by controlling water activity, is reported.

A simple and novel peptide bond formation by copper (II) complex.

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