52776-48-4

Upstream product

• 3592-47-0 Benzaldehyde-d 
• 650-51-1 sodium trichloroacetate 
• 67-66-3 chloroform 
• 65-85-0 benzoic acid 
• 2902-69-4 2,2,2-trichloroacetophenone 
• 21175-64-4 1,1-dideuteriophenylmethanol 

Downstream Products

• 3240-11-7 Phenylacetylene-d1 
• 60507-03-1 acetophenone-d1 
• 5284-45-7 ((Z)-2-chloro-1-deuterio-vinyl)-benzene 
• 943148-97-8 2-chloro-2-deuterio-1-phenyl-ethanone 

Relevant academic research and scientific papers

Copper(I)-promoted synthesis of chloromethyl ketones from trichloromethyl carbinols

(Chemical Equation Presented) Reaction of several trichloromethyl carbinols with 2 equiv of CuCl/bpy in refluxing DCE for 3 h afforded chloromethyl ketones in excellent yield by 1,2-H shift in the copper-chlorocarbenoid intermediate.

A mechanistic study of the chromium(II)-mediated transformations of trichloromethyl alkyls and carbinols: evidence for carbene, carbyne, and carbenoid intermediates

Using CrCl2 in THF at room temperature, trichloromethyl carbinols and trichloromethylalkanes are readily transformed to the highly reactive α-chlorocarbenes, carbynes and α-chloro-α-chromium(III) vinylidene carbenoids. A mechanistic study is carried out to determine the nature of the intermediates.