3843-99-0

Upstream product

• 124-38-9 carbon dioxide 
• 52780-15-1 3'-bromo-2'-methylbenzonitrile 
• 76006-33-2 3-bromo-2-methylbenzoic acid 
• 21900-48-1 3-bromo-2-methylbenzoic acid chloride 
• 919363-09-0 3-bromo-2-methylbenzamide 
• 55289-36-6 3-bromo-2-methylaniline 
• 52130-17-3 3-amino-2-methylbenzoic acid 
• 80762-49-8 2-(m-chlorophenyl)-4,4-dimethyl-4,5-dihydrooxazole 
• 93340-34-2 3-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-2-methyl-benzonitrile 

Downstream Products

• 2239273-34-6 3-(2-amino-6-(1-((6-(2-hydroxypropan-2-yl)pyridin-2-yl)methyl)-1H-1,2,3-triazol-4-yl)pyrimidin-4-yl)-2-methylbenzonitrile 
• 35256-74-7 2-methyl-3-cyano-benzoyl chloride 
• 1092448-32-2 2-(3-cyano-2-methyl-benzoylamino)-indan-2-carboxylic acid ethyl ester 
• 35256-76-9 2-methyl-3-(p-chlorobenzoyl)-benzoic acid 
• 93340-09-1 methyl 3-cyano-2-methylbenzoate 
• 55026-74-9 2-methyl-3-(p-chlorobenzoyl)-phenylacetic acid 
• 28269-31-0 dimethyl 2-methylbenzene-1,3-dicarboxylate 
• 15120-47-5 2-methyl-1,3-benzenedicarbocylic acid 

Relevant academic research and scientific papers

Development of a Scalable and Practical Synthesis of AB928, a Dual A2a/A2bReceptor Antagonist

AB928 is a potent and selective dual antagonist of the A2a and A2b receptors, which is currently in clinical trials. Here, we report the development of two scalable and practical syntheses of AB928. The first-generation synthesis was used to successfully

PROCESSES FOR PREPARING AMINOPYRIMIDINE COMPOUNDS

Provided herein are improved processes for preparing aminopyrimidine compounds of Formula (I). The disclosed processes advantageously proceed through a β-diketoester intermediate of Formula (A) and avoid the direct linking of a pyrimidine and phenyl moiet

QUINOLINE DERIVATIVE

This invention relates to a compound (a quinoline derivative) represented by the formula (I): STR1 The quinoline derivative of this invention has a strong leukotriene antagonistic action and is extremely useful as an antiallergic medicine and an anti-inflammatory medicine.

TANDEM ADDITION-REARRANGEMENT OF NITRILE ANIONS TO BENZYNE. A CONVENIENT SYNTHESIS OF 3-CYANO-2-ALKYL BENZOIC ACIDS AND BENZALDEHYDES.

Benzynes derived from aryloxazolines react with lithio-alkyl nitriles to give addition followed by cyclization to benzocyclobutanone imines which fragment to the title products.