52783-67-2Relevant articles and documents
Cascade synthesis of polyoxygenated 6H,11H-[2]benzopyrano-[4,3-c][1] benzopyran-11-ones
Naumov, Mikael I.,Sutirin, Sergey A.,Shavyrin, Andrey S.,Ganina, Olga G.,Beletskaya, Irina P.,Bourgarel-Rey, Veronique,Combes, Sebastien,Finet, Jean-Pierre,Fedorov, Alexey Yu.
, p. 3293 - 3301 (2008/02/03)
(Chemical Equation Presented) 2-(Methoxymethoxymethyl)aryllead triacetates, obtained in situ from the corresponding arylboronic acids, reacted with 4-hydroxycoumarins, leading to 3-(2-methoxymethoxymethyl)aryl-4-hydroxycoumarin derivatives in good to high yields. These compounds underwent a cascade sequence of reactions, deprotection-halogenation-annulation, to afford polyoxygenated tetracyclic 6H, 11H-[2]benzopyrano-[4,3-c] [1]benzopyran-11-ones in good yields. Some compounds showed a moderate cytotoxicity against human epithelial mammary HBL100 cells.
A facile and regioselective synthesis of donor-substituted 2-(2-halophenyl)acetaldehyde acetals
Wunsch,Nerdinger
, p. 301 - 305 (2007/10/02)
Starting from vanillin (5a) a facile and high yielding procedure for the preparation of the donor substituted (2-bromophenyl)- and (2-iodophenyl)-acetaldehyde acetals 13c and 16c is described. Homologization of O-benzylvanillin to obtain the phenylacetaldehyde acetal 15c succeeds by Wittig reaction with the phosphonium chloride 11 and subsequent addition of methanol. 15c is brominated with pyridinium bromide perbromide in methanol to yield the bromo acetal 13c in 65% yield from vanillin. Iodination of 15c with iodine and iodic acid leads to the iodo acetal 16c.