5279-49-2Relevant academic research and scientific papers
Highly Chemoselective NH- and O-Transfer to Thiols Using Hypervalent Iodine Reagents: Synthesis of Sulfonimidates and Sulfonamides
Tota, Arianna,St John-Campbell, Sahra,Briggs, Edward L.,Estévez, Gala Ogalla,Afonso, Michelle,Degennaro, Leonardo,Luisi, Renzo,Bull, James A.
supporting information, p. 2599 - 2602 (2018/05/22)
Aryl thiols can be selectively converted to sulfonimidates or sulfonamides with three new S-X connections being made selectively in one pot. Using hypervalent iodine reagents in the presence of ammonium carbamate, NH- and O-groups are transferred under mild and practical conditions. Reducing the loading of ammonium carbamate changed the product distribution, converting the sulfonimidate to the sulfonamide. Studies into the possible intermediate species are presented, suggesting that multiple pathways may be possible via sulfinate esters, or related intermediates, with each species forming the same products.
SULFONYLUREAS AND RELATED COMPOUNDS AND USE OF SAME
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Page/Page column 121, (2016/09/15)
ABSTRACT The present invention provides for certain sulfonyl ureas and related compounds which have advantageous properties and show useful activity in the inhibition of activation of the NLRP3 inflammasome. Such compounds are useful in the treatment of a wide range of disorders in which the inflammation process, or more specifically the NLRP3 inflammasome, have been implicated as being a key factor.
ANTITUMOR BENZOYLSULFONAMIDES
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Page 8, (2008/06/13)
The present invention provides antitumor compounds of the formula (I); and antitumor methods.
Diarylsulfonylureas for use in treating secretory diarrhea
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, (2008/06/13)
This invention provides methods of treating secretory diarrhea or cystic fibrosis in a mammal which comprises administering to a mammal in need thereof an effective amount of diarylsulfonylurea. This invention also describes specific diarylsulfonylureas f
Antitumor compositions and methods of treatment
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, (2008/06/13)
This invention provides the use of certain tetra-substituted imidazolidin-2-one derivatives in the treatment of susceptible neoplasms in mammals. Also provided are certain novel tetra-substituted imidazolidin-2-one derivatives and pharmaceutical formulati
Anti-tumor method and compounds
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, (2008/06/13)
This invention provides certain N-[(phenyl)amino]carbonyl-bicyclicsulfonamide sulfonamide derivatives, their pharmaceutical formulations, and their use in the treatment of susceptible neoplasms in mammals.
Synthesis of bicyclic aromatic sulfonyl chlorides
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, (2008/06/13)
A process for preparing bicyclic aromatic sulfonyl chlorides of the formula wherein, n is 1 or 2;, A is -O- or -CH2-; and, B is -O-, -CH2-, or -NCH3-;, provided at least one of A or B is -O-,which comprises reacting a compound of the formula with a Villsmeier reagent of the formula The bicyclic aromatic sulfonyl chlorides produced by the process can be used to prepare pharmaceutically useful sulfonylureas.
