52827-02-8 Usage
Description
[(4-methylphenyl)(nitroso)amino]acetic acid, commonly referred to as MPA, is a chemical compound characterized by the molecular formula C9H10N2O3. It belongs to the nitrosamine class of organic compounds, which are known for containing the nitroso functional group. MPA is recognized for its role as a reagent in the fields of organic synthesis and pharmaceutical research. Additionally, it has been a subject of interest for its potential applications in treating various medical conditions. Despite its potential benefits, MPA has also been investigated for its carcinogenic properties due to its classification as a nitrosamine. The chemical structure of MPA comprises a phenyl group, a nitroso group, and an aminoacetic acid group, with its properties and uses remaining an active area of research.
Uses
Used in Organic Synthesis:
[(4-methylphenyl)(nitroso)amino]acetic acid is used as a reagent in organic synthesis for its ability to facilitate various chemical reactions and contribute to the formation of complex organic molecules.
Used in Pharmaceutical Research:
In the pharmaceutical industry, [(4-methylphenyl)(nitroso)amino]acetic acid is utilized as a reagent to aid in the development and synthesis of new drugs, potentially leading to the discovery of novel therapeutic agents.
Used in Medical Condition Treatment:
MPA is being studied for its potential use in treating various medical conditions, although further research is necessary to fully understand its therapeutic potential and safety.
Used in Carcinogenicity Studies:
The carcinogenic properties of [(4-methylphenyl)(nitroso)amino]acetic acid are being investigated to better understand the risks associated with nitrosamine compounds and to inform the development of safer alternatives or mitigation strategies in the pharmaceutical and chemical industries.
Check Digit Verification of cas no
The CAS Registry Mumber 52827-02-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,2,8,2 and 7 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 52827-02:
(7*5)+(6*2)+(5*8)+(4*2)+(3*7)+(2*0)+(1*2)=118
118 % 10 = 8
So 52827-02-8 is a valid CAS Registry Number.
52827-02-8Relevant articles and documents
Novel sydnone derivatives carrying azidomethyl-1,2, 4-oxadiazole unit and their 1,3-dipolar cycloadditions
Dürüst, Ya?ar,Y?ld?z, Elif,Karaku?, Hamza,Kariuki, Benson M.
, p. 660 - 670 (2017/03/24)
A series of 1,2,4-oxadiazolymethyl sydnones carrying azido group were synthesized and subjected to react with a variety of alkenic and acetylenic dipolarophilic reagents; N-phenyl maleimide, phenyl vinyl sulfone, and phenyl propiolic acid. All the new products are identified by spectral/physical data including high-resolution mass measurements and X-ray diffraction data.
One-pot synthesis of 1,4-disubstituted pyrazoles from arylglycines via copper-catalyzed sydnone-alkyne cycloaddition reaction
Specklin, Simon,Decuypere, Elodie,Plougastel, Lucie,Aliani, Soifia,Taran, Frédéric
, p. 7772 - 7777 (2014/10/15)
A robust method for constructing 1,4-pyrazoles from arylglycines was developed using the copper-catalyzed sydnone-alkyne cycloaddition reaction. The procedure offers a straightforward and general route to the pyrazole heterocycle through a three-step one-pot procedure.
Regioselective reaction: Synthesis, characterization and pharmacological activity of some new Mannich and Schiff bases containing sydnone
Nithinchandra,Kalluraya,Aamir,Shabaraya
experimental part, p. 597 - 604 (2012/09/11)
A novel series of 1-substituted aminomethyl-3-[1-(4-isobutylphenyl)ethyl]- 4-(3-aryl-4-sydnonylidene) amino-1,2,4-triazol-5-thiones (9), was prepared from the 3-[1-(4-isobutylphenyl)ethyl]-4-(3-aryl-4-sydnonylidene) amino 5-mercapto-1,2,4-triazoles (8) by aminomethylation with formaldehyde and secondary amine. The structures of Schiff bases (8) and Mannich bases (9) were characterized on the basis of IR, NMR, mass spectra1 data and elemental analysis. The newly synthesized compounds were screened for their anti-inflammatory and analgesic activities. Mannich bases (9) carrying piperidine and morpholine residues showed promising anti-inflammatory and analgesic activity.
