52829-93-3

Upstream product

• 52829-88-6 5-methylene-N-phenyl-4,5-dihydrothiazol-2-amine 
• 137768-73-1 1-isothiocyanatopropa-1,2-diene 
• 62-53-3 aniline 
• 103-72-0 phenyl isothiocyanate 
• 1170696-62-4 N-(2-bromo-allyl)-N'-phenyl-thiourea 
• 2450-71-7 Propargylamine 

Relevant academic research and scientific papers

Microwave-Assisted Domino Reactions of Propargylamines with Isothiocyanates: Selective Synthesis of 2-Aminothiazoles and 2-Amino-4-methylenethiazolines

A simple and versatile microwave-assisted protocol for the synthesis of 2-aminothiazoles has been developed. The domino reaction of propargylamines and isothiocyanates in the presence of catalytic PTSA leads to the selective synthesis of 2-aminothiazoles

Intramolecular nucleophilic substitution at an sp2 carbon: synthesis of substituted thiazoles and imidazole-2-thiones

The nucleophilic substitution reactions of vinylic bromides with intramolecular thioamide or thiourea moieties proceed to give a series of substituted thiazoles and imidazole-2-thiones.

Rearrangement reactions; 14: Synthesis of functionalized thiazoles via attack of heteroatom nucleophiles on allenyl isothiocyanates

Treatment of allenyl isothiocyanates with sulfur-, oxygen-, nitrogen- or hydride-containing nucleophiles such as propane-2-thiol, thiophenol, hydrogen sulfide, alcohols, phenol or aqueous NaOH, NH3, primary or secondary aliphatic or aromatic amines, N,N,N′,N′-tetramethylguanidine or sodium cyanoborohydride resulted in ring closure to generate thiazoles bearing a functionality at position C-2 in most cases. Moreover, we report the first examples of aromatic miazole-2-phosphonates prepared by the same strategy using dialkyl or diphenyl phosphites as nucleophiles. Georg Thieme Verlag Stuttgart.

SYNTHESIS AND REACTIONS OF NEW VINYL ISOTHIOCYANATES

New vinyl isothiocyanates, which can be prepared from easily accessible thiocyanates by sigmatropic shifts, show unusually high reactivity used for the synthesis of heterocyclic sulfur compounds.