5285-41-6

Usage

Uses

Used in Research Applications:
5,6-dichlorobenzoxazol-2(3H)-one is used as a fluorescent tracer for detecting oxidative stress in various biological samples. Its ability to fluoresce under specific conditions makes it a valuable tool for researchers studying the effects of oxidative stress on biological systems.
Used in Chemical Synthesis:
5,6-dichlorobenzoxazol-2(3H)-one serves as a chemical intermediate in the synthesis of other organic compounds. Its unique structure allows it to be a key component in the creation of new molecules with potential applications in various industries.
Used in Environmental Monitoring:
Due to its fluorescent properties, 5,6-dichlorobenzoxazol-2(3H)-one can be employed in environmental monitoring to detect and measure the presence of certain pollutants or contaminants. This can help in assessing the quality of air, water, or soil samples.
Used in Pharmaceutical Development:
5,6-dichlorobenzoxazol-2(3H)-one may also be used in the development of pharmaceuticals, particularly as a starting material for the synthesis of new drugs. Its chemical properties make it a promising candidate for creating compounds with potential therapeutic effects.
Safety and Handling:
5,6-dichlorobenzoxazol-2(3H)-one is considered a hazardous substance and should be handled and stored with care. It poses potential health and environmental risks, and proper safety measures should be taken to minimize exposure and ensure the well-being of individuals and the environment.

InChI:InChI=1/C7H3Cl2NO2/c8-3-1-5-6(2-4(3)9)12-7(11)10-5/h1-2H,(H,10,11)

Upstream product

• 59-49-4 2-Benzoxazolinone 
• 28443-57-4 2-amino-4,5-dichlorophenol 
• 530-62-1 1,1'-carbonyldiimidazole 
• 61-80-3 zoxazolamine 
• 95-25-0 5-chloro-2-benzoxazolinone 
• 64037-12-3 5,6-dichlorobenzo[d]oxazol-2-amine 

Downstream Products

• 20844-83-1 3-(3-Methoxypropyl)-5,6-dichlor-2-benzoxazolinon 
• 71865-29-7 5,6-dichlorobenzoxazole-2-thione 
• 19231-21-1 5,6-Dichlor-3-<1'-(2',3',4'-tri-O-benzoyl-β-D-ribopyranosyl)>-2-benzoxazolon 
• 18845-24-4 3-(3-Chlorpropyl)-5,6-dichlor-2-benzoxazolinon 

Relevant academic research and scientific papers

A method for synthesizing anti-mildew agent O

The invention discloses a synthesis method of mildew preventive O. The synthesis method comprises the following steps: carrying out condensation reaction on 5-chloro-2-hydroxyaniline and urea under existence of hydrochloric acid to prepare 5-chlorobenzene oxazolone intermediate; carrying out substitution reaction on 5-chlorobenzene oxazolone, the hydrochloric acid and aqueous hydrogen peroxide solution under existence of polar solvent acetic acid, wherein the mass ratio of the 5-chlorobenzene oxazolone to the acetic acid to the hydrochloric acid to the aqueous hydrogen peroxide solution is 1 to 2.5 to 1.25 to 0.9; the reaction temperature is controlled at 50-75 DEG C; the reaction time is 3 hours; carrying out post-treatment such as cooling, washing and the like on the prepared product, so as to obtain a mildew preventive O crude product; recrystallizing by 95% of ethanol, so as to obtain a pure mildew preventive O product. The mildew preventive O is similar to white in appearance; the content is 96%; the melting point range is 185.0 DEG C to 187.0 DEG C; the product yield is over 80%.

Benzoxazolone Carboxamides as Potent Acid Ceramidase Inhibitors: Synthesis and Structure-Activity Relationship (SAR) Studies

Ceramides are lipid-derived intracellular messengers involved in the control of senescence, inflammation, and apoptosis. The cysteine amidase, acid ceramidase (AC), hydrolyzes these substances into sphingosine and fatty acid and, by doing so, regulates their signaling activity. AC inhibitors may be useful in the treatment of pathological conditions, such as cancer, in which ceramide levels are abnormally reduced. Here, we present a systematic SAR investigation of the benzoxazolone carboxamides, a recently described class of AC inhibitors that display high potency and systemic activity in mice. We examined a diverse series of substitutions on both benzoxazolone ring and carboxamide side chain. Several modifications enhanced potency and stability, and one key compound with a balanced activity-stability profile (14) was found to inhibit AC activity in mouse lungs and cerebral cortex after systemic administration. The results expand our arsenal of AC inhibitors, thereby facilitating the use of these compounds as pharmacological tools and their potential development as drug leads.

BENZOXAZOLONE DERIVATIVES AS ACID CERAMIDASE INHIBITORS, AND THEIR USE AS MEDICAMENTS

The present invention relates to benzoxazolone derivatives as acid ceramidase inhibitors, pharmaceutical compositions containing these inhibitors and methods of inhibiting acid ceramidase for the treatment of disorders in which modulation of the levels of ceramide is clinically relevant. The invention also provides benzoxazolone derivatives for use as a medicament in the treatment of cancer, inflammation, pain, inflammatory pain or pulmonary diseases.