5285-41-6

Basic information

• Product Name: 5,6-dichlorobenzoxazol-2(3H)-one
• Synonyms: 5,6-dichlorobenzoxazol-2(3H)-one;5,6-Dichloro-2(3H)-benzoxazolone;2(3H)-Benzoxazolone, 5,6-dichloro-;2-Benzoxazolinone, 5,6-dichloro-;5,6-Dichloro-2-benzoxazolinone;Nsc24962;Wln: T56 bmvoj gg hg;5,6-Dichloro-3H-benzooxazol-2-one
• CAS NO: 5285-41-6
• Molecular Formula: C₇H₃Cl₂NO₂
• Molecular Weight: 204.01022
• EINECS: 226-121-0
• Mol File: 5285-41-6.mol
• Article Data: 4

Chemical Properties

• Melting Point: 196-197 °C(Solv: ethanol (64-17-5))
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.619g/cm³
• Refractive Index: 1.616
• PKA: 7.30±0.70(Predicted)
• CAS DataBase Reference: 5,6-dichlorobenzoxazol-2(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6-dichlorobenzoxazol-2(3H)-one(5285-41-6)
• EPA Substance Registry System: 5,6-dichlorobenzoxazol-2(3H)-one(5285-41-6)

Safety Data

• Hazardous Substances Data: 5285-41-6(Hazardous Substances Data)

Usage

General Description

5,6-dichlorobenzoxazol-2(3H)-one is a chemical compound with the molecular formula C7H3Cl2NO2. It is a derivative of benzoxazolone, containing two chlorine atoms in the 5 and 6 positions of the benzene ring. 5,6-dichlorobenzoxazol-2(3H)-one is commonly used as a fluorescent tracer for the detection of oxidative stress in various biological samples. It can also be used as a chemical intermediate in the synthesis of other organic compounds. 5,6-dichlorobenzoxazol-2(3H)-one is typically handled and stored with care, as it is considered to be a hazardous substance with potential health and environmental risks.

InChI:InChI=1/C7H3Cl2NO2/c8-3-1-5-6(2-4(3)9)12-7(11)10-5/h1-2H,(H,10,11)

Upstream product

• 28443-57-4 2-amino-4,5-dichlorophenol 
• 530-62-1 1,1'-carbonyldiimidazole 
• 61-80-3 zoxazolamine 
• 95-25-0 5-chloro-2-benzoxazolinone 
• 64037-12-3 5,6-dichlorobenzo[d]oxazol-2-amine 
• 59-49-4 2-Benzoxazolinone 

Downstream Products

• 20844-83-1 3-(3-Methoxypropyl)-5,6-dichlor-2-benzoxazolinon 
• 71865-29-7 5,6-dichlorobenzoxazole-2-thione 
• 19231-21-1 5,6-Dichlor-3-<1'-(2',3',4'-tri-O-benzoyl-β-D-ribopyranosyl)>-2-benzoxazolon 
• 18845-24-4 3-(3-Chlorpropyl)-5,6-dichlor-2-benzoxazolinon 

Relevant articles and documents

A method for synthesizing anti-mildew agent O

The invention discloses a synthesis method of mildew preventive O. The synthesis method comprises the following steps: carrying out condensation reaction on 5-chloro-2-hydroxyaniline and urea under existence of hydrochloric acid to prepare 5-chlorobenzene oxazolone intermediate; carrying out substitution reaction on 5-chlorobenzene oxazolone, the hydrochloric acid and aqueous hydrogen peroxide solution under existence of polar solvent acetic acid, wherein the mass ratio of the 5-chlorobenzene oxazolone to the acetic acid to the hydrochloric acid to the aqueous hydrogen peroxide solution is 1 to 2.5 to 1.25 to 0.9; the reaction temperature is controlled at 50-75 DEG C; the reaction time is 3 hours; carrying out post-treatment such as cooling, washing and the like on the prepared product, so as to obtain a mildew preventive O crude product; recrystallizing by 95% of ethanol, so as to obtain a pure mildew preventive O product. The mildew preventive O is similar to white in appearance; the content is 96%; the melting point range is 185.0 DEG C to 187.0 DEG C; the product yield is over 80%.

BENZOXAZOLONE DERIVATIVES AS ACID CERAMIDASE INHIBITORS, AND THEIR USE AS MEDICAMENTS

The present invention relates to benzoxazolone derivatives as acid ceramidase inhibitors, pharmaceutical compositions containing these inhibitors and methods of inhibiting acid ceramidase for the treatment of disorders in which modulation of the levels of ceramide is clinically relevant. The invention also provides benzoxazolone derivatives for use as a medicament in the treatment of cancer, inflammation, pain, inflammatory pain or pulmonary diseases.