52858-57-8

Basic information

• Product Name: THPA
• Synonyms: 2-Propenoic acid tetrahydro-2H-pyran-2-yl ester;2-Tetrahydropyranyl acrylate;2-Tetrahydropyranyl acrylate contains =97%
• CAS NO: 52858-57-8
• Molecular Formula: C8H12O3
• Molecular Weight: 156.17908
• Mol File: 52858-57-8.mol
• Article Data: 3

Chemical Properties

• Flash Point: 80℃
• Appearance: /
• Density: 1.05 g/mL at 25 °C(lit.)
• Refractive Index: n20/D1.457
• Storage Temp.: 2-8°C
• CAS DataBase Reference: THPA(CAS DataBase Reference)
• NIST Chemistry Reference: THPA(52858-57-8)
• EPA Substance Registry System: THPA(52858-57-8)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• RIDADR: NA 1993 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 52858-57-8(Hazardous Substances Data)

Usage

Uses

This acrylate is commonly used in the formation of photoresists, but can also be used as a protected acrylic acid.

Upstream product

• 110-87-2 3,4-dihydro-2H-pyran 
• 92-84-2 10H-phenothiazine 
• 79-10-7 acrylic acid 

Relevant articles and documents

Microfluidically fabricated pH-responsive anionic amphiphilic microgels for drug release

Amphiphilic microgels of different composition based on the hydrophilic, pH-responsive acrylic acid (AA) and the hydrophobic, non-ionic n-butyl acrylate (BuA) were synthesised using a lab-on-a-chip device. Hydrophobic droplets were generated via a microfluidic platform that contained a protected form of AA, BuA, the hydrophobic crosslinker, ethylene glycol dimethacrylate (EGDMA), and a free radical initiator in an organic solvent. These hydrophobic droplets were photopolymerised within the microfluidic channels and subsequently hydrolysed, enabling an integrated platform for the rapid, automated, and in situ production of anionic amphiphilic microgels. The amphiphilic microgels did not feature the conventional core-shell structure but were instead based on random amphiphilic copolymers of AA and BuA and hydrophobic crosslinks. Due to their amphiphilic nature they were able to encapsulate and deliver both hydrophobic and hydrophilic moieties. The model drug delivery and the swelling ability of the microgels were influenced by the pH of the surrounding aqueous solution and the hydrophobic content of the microgels.

Catalyzed process for reacting carboxylic acids with vinyl ethers

The present invention relates to a process for the reaction of carboxylic acids with vinyl ethers using a non-polymeric pyridine hydrochloride and/or polymeric vinylpyridine hydrochloride as a catalyst.