52867-35-3Relevant academic research and scientific papers
3-AMINO-4,4-DISUBSTITUTED-5-CARBOXYMETHYL-Δ2-1,3,4-OXADIAZOLIN-4-IUM CHLORIDES AND THEIR RECYCLIZATION IN ACETIC ANHYDRIDE
Kauss, V. Ya.,Kalvin'sh, I. Ya.
, p. 1449 - 1452 (1992)
2-Methylamino-4,4-disubstituted-5-carboethoxymethyl-Δ2-1,3,4-oxadiazolin-4-ium chlorides were obtained from the reaction of 1,1-disubstituted-4-methylsemicarbazides with ethyl propiolate in the presence of hydrochloric acid.After hydrolysis of
HETEROARYLPHENOXY BENZAMIDE KAPPA OPIOID LIGANDS
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Paragraph 0245; 0246, (2018/06/09)
The present invention provides compounds of Formula I: and pharmaceutically acceptable salts thereof wherein the variables R1, R2, R3, R4, R9, X, m and n are as defined herein; processes for the prepa
HETEROAROMATIC DERIVATIVES AS NIK INHIBITORS
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Page/Page column 339, (2018/02/03)
The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, and in particular to inhibitors of NF-κB-inducing kinase (NIK - also known as MAP3K14) useful for treating diseases such as cancer, inflammatory disorders, metabolic disorders and autoimmune disorders. The invention is also directed to pharmaceutical compositions comprising such compounds, and to the use of such compounds or pharmaceutical compositions for the prevention or treatment of diseases such as cancer, inflammatory disorders, metabolic disorders including obesity and diabetes, and autoimmune disorders.
Fused Bicyclic Kinase Inhibitors
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Page/Page column 51, (2011/11/30)
Compounds of Formula I, as shown below and defined herein: pharmaceutically acceptable salts thereof, synthesis, intermediates, formulations, and methods of disease treatment therewith, including treatment of cancers, such as tumors driven at least in part by at least one of RON, MET or ALK. This Abstract is not limiting of the invention.
Method for producing 1-substituted 5-Hydroxypyrazoles
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, (2008/06/13)
The invention relates to a process for preparing 1-substituted 5- and/or 3-hydroxypyrazoles of the formulae I and II in which R1 is C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C6-cycloalkyl or C1-C4-alkoxy, where these groups may be substituted by halogen, C1-C4-alkoxy, phenoxy, C1-C6-alkoxycarbonyl, C1-C6-alkylthiocarbonyl or by a cyclic ring system having 3-14 ring atoms, which comprises reactingan alkyl 3-alkoxyacrylate of the formula III in which R2, R3 independently of one another are C1-C6-alkyl or C3-C6-cycloalkyl with a hydrazine of the formula IV in which R1 is as defined abovea) at a pH of 6-11 to give 5-hydroxypyrazoles of the formula I orb) at a pH of 11-14 to give 3-hydroxypyrazoles of the formula II.
Process for the preparation of pyrazolones
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, (2008/06/13)
A process for the preparation of pyrazolone derivatives represented by the general formula STR1 wherein R is a hydrogen atom, an alkyl group, an allyl group, an aryl group or an aralkyl group, and R1 and R2 are, respectively, a hydrogen atom, an alkyl group or a phenyl group which may have a substituent, comprising reacting a 2,3-dihalocarboxylic acid derivative or a 2-haloacrylic acid derivative with a hydrazine derivative. A pyrazolone or 1-substituted-3-pyrazolones useful as intermediate starting materials for the synthesis of agricultural chemicals, medicine and chemical compounds can be easily and cheaply prepared from widely used industrial starting materials.
REGIOSELECTIVE NUCLEOPHILIC SUBSTITUTION IN ACTIVATED 1-AMINOPYRAZOLIUM CATIONS: A FACILE SYNTHESIS OF 5-SUBSTITUTED 1-METHYLPYRAZOLES
Bruix, Marta,Castellanos, M. Luisa,Martin, M. Rosario,Mendoza, Javier de
, p. 5485 - 5488 (2007/10/02)
5-Substituted 1-methylpyrazoles were easily obtained in good yields by the attack of nucleophiles (NaCN, H2O, EtSH, pyrazole, imidazole) to 2,6-dimethyl-1-(2-methylpyrazol-1-io)-4-phenylpyridinium bistetrafluoroborate (1b), without significant formation o
