52867-35-3

Basic information

• Product Name: 1-Methyl-1H-pyrazol-3(2H)-one
• Synonyms: 1-Methyl-1,2-dihydro-3H-pyrazol-3-one;1-Methyl-3-pyrazolone;3-Hydroxy-1-methylpyrazole;1-Methyl-1H-pyrazol-3(2H);EOS-62072;1-METHYL-1H-PYRAZOL-3-OL(WX900134);52867-35-3
• CAS NO: 52867-35-3
• Molecular Formula: C₄H₆N₂O
• Molecular Weight: 98.10324
• Mol File: 52867-35-3.mol
• Article Data: 7

Chemical Properties

• Melting Point: 124-128°C
• Appearance: /
• Density: 1.146±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 8.98±0.70(Predicted)
• CAS DataBase Reference: 1-Methyl-1H-pyrazol-3(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methyl-1H-pyrazol-3(2H)-one(52867-35-3)
• EPA Substance Registry System: 1-Methyl-1H-pyrazol-3(2H)-one(52867-35-3)

Safety Data

• Hazard Codes: Xi
• Statements: 37/38-41
• Safety Statements: 26-39
• WGK Germany: 3
• Hazardous Substances Data: 52867-35-3(Hazardous Substances Data)

Usage

General Description

1-Methyl-1H-pyrazol-3(2H)-one, often simplified to 'MPO', is a specialized chemical compound with the molecular formula C4H6N2O. It belongs to the class of compounds known as pyrazolones, which are polycyclic aromatic compounds containing a five-membered ring with two nitrogen atoms and three carbon atoms. MPO features in various organic syntheses and has also found applications in the production of agrochemicals, pharmaceuticals, and dyes. Its specific properties may vary, but in general, it is a crystalline powder that is typically stable but may pose safety hazards if improperly handled.

Upstream product

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Downstream Products

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Relevant articles and documents

3-AMINO-4,4-DISUBSTITUTED-5-CARBOXYMETHYL-Δ2-1,3,4-OXADIAZOLIN-4-IUM CHLORIDES AND THEIR RECYCLIZATION IN ACETIC ANHYDRIDE

2-Methylamino-4,4-disubstituted-5-carboethoxymethyl-Δ2-1,3,4-oxadiazolin-4-ium chlorides were obtained from the reaction of 1,1-disubstituted-4-methylsemicarbazides with ethyl propiolate in the presence of hydrochloric acid.After hydrolysis of

HETEROAROMATIC DERIVATIVES AS NIK INHIBITORS

The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, and in particular to inhibitors of NF-κB-inducing kinase (NIK - also known as MAP3K14) useful for treating diseases such as cancer, inflammatory disorders, metabolic disorders and autoimmune disorders. The invention is also directed to pharmaceutical compositions comprising such compounds, and to the use of such compounds or pharmaceutical compositions for the prevention or treatment of diseases such as cancer, inflammatory disorders, metabolic disorders including obesity and diabetes, and autoimmune disorders.

Method for producing 1-substituted 5-Hydroxypyrazoles

The invention relates to a process for preparing 1-substituted 5- and/or 3-hydroxypyrazoles of the formulae I and II in which R1 is C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C6-cycloalkyl or C1-C4-alkoxy, where these groups may be substituted by halogen, C1-C4-alkoxy, phenoxy, C1-C6-alkoxycarbonyl, C1-C6-alkylthiocarbonyl or by a cyclic ring system having 3-14 ring atoms, which comprises reactingan alkyl 3-alkoxyacrylate of the formula III in which R2, R3 independently of one another are C1-C6-alkyl or C3-C6-cycloalkyl with a hydrazine of the formula IV in which R1 is as defined abovea) at a pH of 6-11 to give 5-hydroxypyrazoles of the formula I orb) at a pH of 11-14 to give 3-hydroxypyrazoles of the formula II.