86625-25-4

Basic information

• Product Name: METHYL 5-HYDROXY-PYRAZOLE-3-CARBOXYLATE
• Synonyms: METHYL 5-HYDROXY-PYRAZOLE-3-CARBOXYLATE;5-HYDROXY-1H-PYRAZOLE-3-CARBOXYLIC ACID METHYL ESTER;Methyl 3-hydroxy-1H-pyrazole-5-carboxylate;5-Hydroxy-1H-pyrazole-3-carboxylic acid ethyl ester;1H-Pyrazole-3-carboxylicacid, 2, 5-dihydro-5-oxo-, methyl ester
• CAS NO: 86625-25-4
• Molecular Formula: C₅H₆N₂O₃
• Molecular Weight: 142.11
• Mol File: 86625-25-4.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Density: 1.338 g/cm³
• Refractive Index: 1.499
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 7.70±0.70(Predicted)
• CAS DataBase Reference: METHYL 5-HYDROXY-PYRAZOLE-3-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 5-HYDROXY-PYRAZOLE-3-CARBOXYLATE(86625-25-4)
• EPA Substance Registry System: METHYL 5-HYDROXY-PYRAZOLE-3-CARBOXYLATE(86625-25-4)

Safety Data

• Hazardous Substances Data: 86625-25-4(Hazardous Substances Data)

Usage

General Description

Methyl 5-hydroxy-pyrazole-3-carboxylate is a chemical compound with the molecular formula C5H6N2O3. It is a pyrazole derivative that contains a methyl group and a hydroxy group. METHYL 5-HYDROXY-PYRAZOLE-3-CARBOXYLATE is commonly used as a building block in the synthesis of various pharmaceuticals, agrochemicals, and other fine chemicals. It is also used in research and development for its unique chemical properties. Methyl 5-hydroxy-pyrazole-3-carboxylate is known for its potential applications in medicinal chemistry and drug discovery due to its ability to modify the activity of certain biological targets.

InChI:InChI=1/C5H6N2O3/c1-10-5(9)3-2-4(8)7-6-3/h2H,1H3,(H2,6,7,8)

Upstream product

• 64-19-7 acetic acid 
• 762-42-5 dimethyl acetylenedicarboxylate 
• 67-56-1 methanol 
• 25007-54-9 Dimethyl 2-oxosuccinate 

Downstream Products

• 52867-42-2 5-hydroxy-2-methyl-2H-pyrazole-3-carboxylic acid methyl ester 
• 1254966-07-8 5-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-2H-pyrazole-3-carboxylic acid methyl ester 
• 1254966-31-8 5-[5-((1S,2R)-1,2-dihydroxy-2-phenyl-ethyl)-3-(4-fluoro-phenyl)-isoxazol-4-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid methyl ester 
• 1254966-38-5 5-[3-butyl-5-(1,2-dihydroxy-2-phenyl-ethyl)-isoxazol-4-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid methyl ester 
• 1254966-32-9 5-[3-(4-fluoro-phenyl)-5-hydroxymethyl-isoxazol-4-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid methyl ester 
• 1254966-30-7 5-[3-(4-fluoro-phenyl)-5-formyl-isoxazol-4-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid methyl ester 
• 1254966-28-3 2-methyl-5-[5-methyl-3-(tetrahydro-pyran-4-yl)-isoxazol-4-ylmethoxy]-2H-pyrazole-3-carboxylic acid methyl ester 
• 1254966-20-5 2-methyl-5-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-2H-pyrazole-3-carboxylic acid methyl ester 
• 926296-28-8 methyl 1-[2-chloro-4-(trifluoromethyl)benzyl]-3-(methoxymethoxy)-1H-pyrazole-5-carboxylate 
• 888738-72-5 methyl 1-benzyl-3-isopropoxy-1H-pyrazole-5-carboxylate 
• 888741-09-1 methyl 1-benzyl-3-(benzyloxy)-1H-pyrazole-5-carboxylate 
• 52867-49-9 1-benzyl-3-hydroxy-5-methoxycarbonyl-1H-pyrazole 
• 762-42-5 dimethyl acetylenedicarboxylate 

Relevant articles and documents

NOVEL HETEROCYCLIC COMPOUNDS AS BET INHIBITORS

Provided are heterocyclic compounds of formula (I) as bromodomain and extraterminal (BET) inhibitors, pharmaceutical compositions comprising the compounds, their synthesis and their use for treating diseases and conditions wherein inhibition of one or more BET bromodomains provides a benefit.

MORPHOLIN-PYRIDINE DERIVATIVES

The present invention relates to compounds of formula (I) wherein X is CR or N; R is hydrogen, halogen or lower alkyl; L is a bond, -C(O)- or -C(O)NH-; Ar is phenyl or a five or six membered heteroaryl group, containing one or two N atoms; R1 i

ISOXAZOLE-PYRAZOLE DERIVATIVES

The present invention is concerned with isoxazole-pyrazole derivatives of formula I, having affinity and selectivity for GABA A α5 receptor, their manufacture, pharmaceutical compositions containing them and their use as medicaments. The active compounds of the present invention are useful as cognitive enhancer or for the therapeutic and/or prophylactic treatment of cognitive disorders like Alzheimer's disease.