528856-86-2Relevant academic research and scientific papers
Photocatalytic Dehydrogenative Cross-Coupling of Alkenes with Alcohols or Azoles without External Oxidant
Yi, Hong,Niu, Linbin,Song, Chunlan,Li, Yiying,Dou, Bowen,Singh, Atul K.,Lei, Aiwen
supporting information, p. 1120 - 1124 (2017/01/18)
Direct cross-coupling between alkenes/R-H or alkenes/RXH is a dream reaction, especially without external oxidants. Inputting energy by photocatalysis and employing a cobalt catalyst as a two-electron acceptor, a direct C?H/X?H cross-coupling with H2evolution has been achieved for C?O and C?N bond formation. A new radical alkenylation using alkene as the redox compound is presented. A wide range of aliphatic alcohols—even long chain alcohols—are tolerated well in this system, providing a new route to multi-substituted enol ether derivatives using simple alkenes. Additionally, this protocol can also be used for N-vinylazole synthesis. Mechanistic insights reveal that the cobalt catalyst oxidizes the photocatalyst to revive the photocatalytic cycle.
Synthesis and structure-activity relationship studies of novel 2-diarylethyl substituted (2-carboxycycloprop-1-yl)glycines as high-affinity group II metabotropic glutamate receptor ligands.
Sorensen, Ulrik S,Bleisch, Thomas J,Kingston, Anne E,Wright, Rebecca A,Johnson, Bryan G,Schoepp, Darryle D,Ornstein, Paul L
, p. 197 - 205 (2007/10/03)
The major excitatory neurotransmitter in the central nervous system, (S)-glutamic acid , activates both ionotropic and metabotropic excitatory amino acid receptors. Its importance in connection to neurological and psychiatric disorders has directed great
