52900-07-9

Upstream product

• 110-91-8 morpholine 
• 106-89-8 epichlorohydrin 
• 5911-08-0 chloro(cyclopropyl)methane 

Downstream Products

• 39849-45-1 1-amino-3-morpholin-4-yl-propan-2-ol 
• 756520-73-7 1-morpholin-4-yl-3-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenoxy]propan-2-ol 

Relevant academic research and scientific papers

Branching of hemicelluloses through an azetidinium salt ring-opening reaction

During the last century there has been a steady increase in the number of publications on practical applications of hemicellulose. Due to the water and moisture sensitivity, poor film-forming ability and lack of thermal processability most of the hemicelluloses need to be chemically modified prior to processing into materials. Within this study we present the results of azetidinium salts as a new functional group for conjugation to polysaccharides. The reactivity of three azetidinium salts on xylan, arabinoxylan and galactoglucomannan was investigated. Carbonyl groups were found to be favorable for the reaction with azetidinium salts and thus the glucuronic acid content in the hemicellulose determines the degree of substitution. TEMPO-oxidation of the hemicelluloses was done which successfully increased the degree of substitution. The highly reactive azetidinium salts are easily synthesized from secondary amines and epichlorohydrin and can be used as a new tool toward functionalization of hemicelluloses into the after sought properties.

Rational drug design based synthesis of novel arylquinolines as anti-tuberculosis agents

A series of novel arylquinoline derivatives was designed retaining significant pharmacophoric features and three dimensional geometry of bedaquiline. In silico ADME study was performed to assess drug likeness and toxicity profiles of the designed molecules. The compounds were evaluated for activity against Mycobacterium tuberculosis H37Rv using Resazurin Microtitre Assay (REMA) plate method and cytotoxicity in VERO C1008 cell line. Several of the synthesized compounds exhibited good antituberculosis activity and selectivity, especially compounds, 12i (MIC: 5.18 μM and MIC/CC 50: 152.86) and 12l (MIC: 5.59 μM and MIC/CC50: 160.57). The study opens up a new platform for the development of arylquinoline based drugs for treating tuberculosis.

Synthesis and pharmacological properties of new derivatives of 4-alkoxy-6-methyl-1h-pyrrolo[3,4-c]pyridine- 1,3(2h)-diones

Synthesis of 2-(2-hydroxy-3-amino)propyl derivatives of 4-alkoxy-6-methyl-1H-pyrrolo[3,4-c]pyridine-1,3(2H)-diones (24-35) is described. The chlorides used in the above synthesis exist mainly in the cyclic forms (18, 20-23). Only chloride with benzhydryl

AMINOHETEROARYL COMPOUNDS AS PROTEIN KINASE INHIBITORS

Aminopyridine and aminopyrazine compounds of formula (1), compositions including these compounds, and methods of their use are provided. Preferred compounds of formula 1 have activity as protein kinase inhibitors, including as inhibitors of c-MET.