52904-17-3

Usage

Uses

Used in Organic Synthesis:
3-(trifluoromethyl)phenyl methanesulfonate is used as a reagent for the introduction of the trifluoromethyl group into organic molecules, which is crucial for enhancing the properties of these molecules, such as their stability and reactivity.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 3-(trifluoromethyl)phenyl methanesulfonate serves as a building block for the synthesis of various biologically active compounds. Its incorporation into these compounds can potentially improve their therapeutic effects and pharmacological properties.
Used in Agrochemical Development:
3-(trifluoromethyl)phenyl methanesulfonate has been studied for its potential use as an intermediate in the development of agrochemicals. Its unique properties may contribute to the creation of more effective and targeted agrochemicals for agricultural applications.
Used in Material Science:
Additionally, 3-(trifluoromethyl)phenyl methanesulfonate is being explored for its potential in the development of materials with specific properties. Its ability to form stable carbon-fluorine bonds can be leveraged to create materials with enhanced characteristics for various applications.

Upstream product

• 75-75-2 methanesulfonic acid 
• 98-17-9 3-Trifluoromethylphenol 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 30934-66-8 1-phenyl-2-<3-(trifluoromethyl)phenyl>-1-ethanone 
• 15952-19-9 2-(3-(trifluoromethyl)phenyl)benzo[d]oxazole 

Relevant academic research and scientific papers

Chromatography-Free and Eco-Friendly Synthesis of Aryl Tosylates and Mesylates

Two chromatography-free and eco-friendly protocols have been developed to synthesize aryl tosylates and mesylates by the tosylation and mesylation of the corresponding hydroxyarenes, respectively. These protocols are superior to other known ones regarding

Palladium-catalyzed carbonylation of aryl tosylates and mesylates

A general protocol for the palladium-catalyzed carbonylation of aryl tosylates and mesylates to form esters has been developed using a catalyst system derived from Pd(OAc)2 and the bulky, bidentate dcpp ligand. The system operates under mild conditions: atmospheric CO pressure and temperatures of 80-110 °C. A broad substrate scope has been demonstrated allowing carbonylation of electron-rich, electron-poor, and heterocyclic tosylates and mesylates, and the reaction shows wide functional group tolerance. Copyright

A simple preparation of aryl methanesulfonates by thermal decomposition of dry arenediazonium O-benzenedisulfonimides in methanesulfonic acid

Aryl methansulfonates 3 (18 examples) were easily prepared by thermal decomposition of dry arenediazonium o-benzenedisulfonimides 1 in methanesulfonic acid (2). The reactions were carried out at temperatures between 60 and 120°C for times between 0.5 and 8 h. The aryl methanesulfonates were obtained in reproducible yield of 70-90%, with few exceptions. In all cases the o-benzenedisulfonimide (4) could be recovered in good yields which can then be reused to prepare the salts 1. When thermal decomposition of salts 1 was carried out in trifluoromethanesulfonic acid (5) at 90-120°C for 1-2 h, aryl trifluoromethanesulfonates 6 were obtained in 73-78% yield (3 examples).