3750-83-2

Upstream product

• 5342-71-2 4-Nitrohexan-3-ol 
• 108-24-7 acetic anhydride 
• 64-19-7 acetic acid 
• 108-03-2 1-Nitropropane 
• 123-38-6 propionaldehyde 
• 75-36-5 acetyl chloride 

Downstream Products

• 4812-22-0 2-ethyl-1-nitro-2-butene 
• 97336-41-9 ethyl 3,4-diethyl-1H-pyrrole-2-carboxylate 
• 147590-65-6 2-benzyl 3,4-diethyl-1H-pyrrole-2-carboxylate 
• 52921-22-9 3-ethyl-1H-pyrrole-2,4-dicarboxylic acid diethyl ester 
• 16200-52-5 3,4-diethyl-1H-pyrrole 
• 130274-66-7 3,4-diethyl-2,5-diformylpyrrole 
• 157873-93-3 3,4-diethyl-1H-pyrrole-2-carboxylic acid 
• 34874-30-1 3,4-diethyl-2-methyl-1H-pyrrole 
• 2683-82-1 2,3,7,8,12,13,17,18-octaethyl-porphyrin 
• 1006-26-4 3,4-diethylpyrrole-2-carbaldehyde 
• 30144-13-9 3,4-diethyl-1-methylpyrrole 
• 865855-40-9 2,5-bis((5-benzyloxycarbonyl-3-n-butyl-4-methyl-2-pyrrolyl)methyl)-3,4-diethyl-1H-pyrrole 

Relevant academic research and scientific papers

Synthesis of 2,2′-bipyrrole-5-carboxaldehydes and their application in the synthesis of B-ring functionalized prodiginines and tambjamines

Facile, versatile, and cost-effective synthetic routes for the preparation of a range of new 3-alkyl-, 4-alkyl-, 3,4-dialkyl-, and 3-halo-4-alkyl-2, 2′-bipyrrole-5-carboxaldehydes have been developed. These 2,2′-bipyrrole-5-carboxaldehydes offer interesting potential as building blocks for making bioactive natural and unnatural products, as demonstrated by the synthesis of B-ring functionalized prodiginines (PGs) and tambjamines.

Compound and method of producing organic semiconductor device

A method of producing an organic semiconductor device is provided in which a layer composed of an organic semiconductor having excellent crystallinity and orientation in a low-temperature region can be formed, and the device can be produced in the air. The method includes forming a layer composed of an organic semiconductor precursor on a base body and irradiating the organic semiconductor precursor with light, wherein the organic semiconductor precursor is a porphyrin compound or an azaporphyrin compound having in its molecule at least one of the structure represented by the following general formula (1) or (2):

Meso-unsubstituted iron corrole in hemoproteins: Remarkable differences in effects on peroxidase activities between myoglobin and horseradish peroxidase

(Figure Presented) Myoglobin (Mb) and horseradish peroxidase (HRP) were both reconstituted with a meso-unsubstituted iron corrole and their electronic configurations and peroxidase activities were investigated. The appearance of the 540 nm band upon incorporation of the iron corrole into apoMb indicates axial coordination by the proximal histidine imidazole in the Mb heme pocket. Based on 1H NMR measurements using the Evans method, the total magnetic susceptibility of the iron corrole reconstituted Mb was evaluated to be S = 3/2. In contrast, although a band does not appear in the vicinity of 540 nm during reconstitution of the iron corrole into the matrix of HRP, a spectrum similar to that of the iron corrole reconstituted Mb is observed upon the addition of dithionite. This observation suggests that the oxidation state of the corrole iron in the reconstituted HRP can be assigned as +4. The catalytic activities of both proteins toward guaiacol oxidation are quite different; the iron corrole reconstituted HRP decelerates H2O2-dependent oxidation of guaiacol, while the same reaction catalyzed by iron corrole reconstituted Mb has the opposite effect and accelerates the reaction. This finding can be attributed to the difference in the oxidation states of the corrole iron when these proteins are in the resting state.

NOVEL COMPOUND AND METHOD OF PRODUCING ORGANIC SEMICONDUCTOR DEVICE

A method of producing an organic semiconductor device is provided in which a layer composed of an organic semiconductor having excellent crystallinity and orientation in a low-temperature region can be formed, and the device can be produced in the air. The method includes forming a layer composed of an organic semiconductor precursor on a base body and irradiating the organic semiconductor precursor with light, wherein the organic semiconductor precursor is a porphyrin compound or an azaporphyrin compound having in its molecule at least one of the structure represented by the following general formula (1) or (2):

Remarkable solvent effect in Barton-Zard pyrrole synthesis: application in an efficient one-step synthesis of pyrrole derivatives

A unique solvent effect encountered in the Barton-Zard pyrrole synthesis was exploited to develop an efficient synthesis of pyrrole-2-esters. The chemistry was extended to a one-pot synthesis of pyrrole-2,4-dicarboxylates.

A new methodology for the preparation of 2-cyanopyrroles and synthesis of porphobilinogen

Condensation of α-acetoxynitro compounds 4a-f with isocyanoacetonitrile (5) using DBU in THF afforded 2-cyano-3,4-substituted pyrroles 6a-f, in good yield. Porphobilinogen (PBG, 12), the key building block for the preparation of tetrapyrrolic natural products, was synthesized from 2-cyano-3,4-substituted pyrrole 6f, in four steps.

A CONVENIENT SYNTHESIS OF 2-CYANOPYRROLES FROM ISOCYANOACETONITRILE

2-Cyano-3,4-substituted pyrroles 2a-e, important intermediates in the synthesis of porphyrins and related compounds, were prepared via base promoted condensation of α-acetoxynitro compound 1a-e with isoacetonitrile (3) in THF, in good yield.

Regioselective synthesis of 5-unsubstituted benzyl pyrrole-2-carboxylates from benzyl isocyanoacetate

A general synthesis of 5-unsubstituted benzyl pyrrole-2-carboxylates was developed based on the reaction of β-nitroacetates with benzyl isocyanoacetate. The advantage of this route over other pyrrole syntheses was the regiochemical control of the substitution pattern on the pyrrole ring.