52923-20-3

Basic information

• Product Name: (S)-2-(2-chlorophenyl)-2-hydroxyacetonitrile
• Synonyms: (S)-2-(2-chlorophenyl)-2-hydroxyacetonitrile
• CAS NO: 52923-20-3
• Molecular Weight: 167.595
• Mol File: 52923-20-3.mol
• Article Data: 25

Chemical Properties

• CAS DataBase Reference: (S)-2-(2-chlorophenyl)-2-hydroxyacetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-(2-chlorophenyl)-2-hydroxyacetonitrile(52923-20-3)
• EPA Substance Registry System: (S)-2-(2-chlorophenyl)-2-hydroxyacetonitrile(52923-20-3)

Safety Data

• Hazardous Substances Data: 52923-20-3(Hazardous Substances Data)

Upstream product

• 74-90-8 hydrogen cyanide 
• 89-98-5 2-chloro-benzaldehyde 
• 7677-24-9 trimethylsilyl cyanide 
• 773837-37-9 sodium cyanide 
• 66985-47-5 2-chloro-α-[(trimethylsilyl)oxy]benzeneacetonitrile 
• 13312-84-0 2-chloromandelonitrile 
• 125803-35-2 2-acetoxy-2-(2-chlorophenyl)acetonitrile 

Downstream Products

• 10421-85-9 (R)-2-chloromandelic acid 
• 10421-85-9 (S)-2-chloromandelic acid 
• 929200-20-4 (S) (2-chlorophenyl)(cyano)methyl 4-methylbenzenesulfonate 

Relevant articles and documents

Stabilization of Hydroxynitrile Lyases from Two Variants of Passion Fruit, Passiflora edulis Sims and Passiflora edulis Forma flavicarpa, by C-Terminal Truncation

Because the synthesis of chiral compounds generally requires a broad range of substrate specificity and stable enzymes, screening for better enzymes and/or improvement of enzyme properties through molecular approaches is necessary for sustainable industri

Hydroxynitrile Lyase Isozymes from Prunus communis: Identification, Characterization and Synthetic Applications

Biocatalysts originating from Badamu (Prunus communis) have been applied to catalyze the asymmetric synthesis of (R)-4-methylsulfanylmandelonitrile, a key building block of thiamphenicol and florfenicol. Here, four hydroxynitrile lyase (HNL) isozymes from Badamu were cloned and heterologously expressed in Pichia pastoris. The biochemical properties and catalytic performances of these isozymes were comprehensively explored to evaluate their efficiency and selectivity in asymmetric synthesis. Among then, PcHNL5 was identified with outstanding activity and enantioselectivity in asymmetric hydrocyanation. Under the optimized mild biphasic reaction conditions, seventeen prochiral aromatic aldehydes were converted to valuable chiral cyanohydrins with good yields (up to 94%) and excellent optical purities (up to >99.9% ee), which provide a facile access to numerous chiral amino alcohols, hypoglycemic agents, angiotension converting enzyme (ACE) inhibitors and β-blockers. This work therefore underlines the importance of discovering the most potent biocatalyst among a group of isozymes for converting unnatural substrates into value-added products. (Figure presented.).

(R)-selective hydroxynitrile lyase variants with a cupin fold having improved substrate scope and the use thereof

The present invention relates to an improved recombinant cupin-hydroxynitrile lyase (HNL), which is capable to catalyze the asymmetric cyanohydrin reaction, wherein the recombinant cupin-HNL comprises at least one amino acid substitution, preferably at le