66985-47-5

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 151-50-8 potassium cyanide 
• 89-98-5 2-chloro-benzaldehyde 
• 7677-24-9 trimethylsilyl cyanide 
• 177755-45-2 2-(3-fluoro-4-methoxyphenyl)-2-[(trimethylsilyl)oxy]acetonitrile 

Downstream Products

• 93554-91-7 (2-Chloro-phenyl)-pyrrolidin-1-yl-acetonitrile; hydrochloride 
• 93554-90-6 (2-chloro-phenyl)-morpholino-acetonitrile; hydrochloride 
• 13511-30-3 ethyl 2-(2-chlorophenyl)-2-hydroxyacetate 
• 53103-42-7 ethyl 2-(2-chlorophenyl)-2-hydroxyacetiminate hydrochloride 
• 87712-74-1 (R,R)-(+)-α-<(1-phenylethyl)amino>-α-(2-chlorophenyl)acetonitrile hydochloride 
• 87712-75-2 (S,S)-(-)-α-<(1-phenylethyl)amino>-α-(2-chlorophenyl)acetonitrile hydochloride 
• 96824-33-8 (S)-(2-Chloro-phenyl)-((R)-1-phenyl-ethylamino)-acetonitrile; hydrochloride 
• 83575-79-5 (2-Chloro-phenyl)-dimethylamino-trimethylsilanyloxy-acetonitrile 
• 49704-74-7 Amino-(2-chloro-phenyl)-acetonitrile; hydrochloride 
• 93554-89-3 (2-Chloro-phenyl)-dimethylamino-acetonitrile; hydrochloride 
• 13312-84-0 2-chloromandelonitrile 
• 6526-67-6 N,N-dimethyl-o-chlorobenzamide 
• 52923-20-3 (S)-2-(2-chlorophenyl)-2-hydroxyacetonitrile 
• 121986-01-4 (R)-2-chloromandelonitrile 

Relevant academic research and scientific papers

Conjugated Bis-Guanidines (CBGs) as β-Diketimine Analogues: Synthesis, Characterization of CBGs/Their Lithium Salts and CBG Li Catalyzed Addition of B?H and TMSCN to Carbonyls

Herein, we report a range of conjugated bis-guanidines (CBGs) L [L={(ArHN)(ArHN)C=N?C=(NAr)(NHAr)}; Ar=2, 6-Me2 - C6H3, (1), 2, 4, 6-Me3?C6H2, (2), 2, 6-Et2?C6H3

Multinuclear transition metal-containing polyoxometalates constructed from Nb/W mixed-addendum precursors: synthesis, structures and catalytic performance

Four new transition metal-containing Nb/W mixed-addendum POM trimers with the formula H19[M4(H2O)x(P2W15Nb3O62)3]·m(HCOOH)·nH2O (M = Cu,x= 15,m=

Discovery of the First in Vivo Active Inhibitors of the Soluble Epoxide Hydrolase Phosphatase Domain

The emerging pharmacological target soluble epoxide hydrolase (sEH) is a bifunctional enzyme exhibiting two different catalytic activities that are located in two distinct domains. Although the physiological role of the C-terminal hydrolase domain is well-investigated, little is known about its phosphatase activity, located in the N-terminal phosphatase domain of sEH (sEH-P). Herein we report the discovery and optimization of the first inhibitor of human and rat sEH-P that is applicable in vivo. X-ray structure analysis of the sEH phosphatase domain complexed with an inhibitor provides insights in the molecular basis of small-molecule sEH-P inhibition and helps to rationalize the structure-activity relationships. 4-(4-(3,4-Dichlorophenyl)-5-phenyloxazol-2-yl)butanoic acid (22b, SWE101) has an excellent pharmacokinetic and pharmacodynamic profile in rats and enables the investigation of the physiological and pathophysiological role of sEH-P in vivo.

Supported Ionic Liquid-Like Phases (SILLPs) as Immobilised Catalysts for the Multistep and Multicatalytic Continuous Flow Synthesis of Chiral Cyanohydrins

Supported Ionic Liquid-Like Phases have been found to be efficient organocatalysts for the synthesis of cyanohydrin esters under solvent-free conditions by an “electrophile-nucleophile dual activation” based on hydrogen bond formation. The combination of

Layered double hydroxides (LDHs): As efficient heterogeneous catalyst for the cyanosilylation of aromatic aldehydes

We report the first application of Layered Double Hydroxides (LDHs) as efficient and novel heterogeneous catalyst for the cyanosilylation of aldehydes with excellent yields and simple work up. The reaction between different aldehydes with electron-withdra

Solvent-free cyanosilylation of aromatic and heteroaryl aldehydes catalyzed by a cationic iron N-heterocyclic carbene complex at ambient temperature under UV irradiation

The cyanosilylation of aromatic aldehydes and heteroaryl aldehydes with trimethylsilyl cyanide (TMSCN) is efficiently catalyzed by an iron complex of the type {[3-isopropyl-1-(1R-phenylethyl)imidazol-2-ylidene]Fe(CO)2}I (3) in presence of UV li

Low-valent magnesium(i)-catalyzed cyanosilylation of ketones

The magnesium(i) complex [(XylNacnac)Mg]2 was employed as a highly efficient catalyst for the cyanosilylation of a variety of ketones with trimethylsilyl cyanide under mild conditions. In contrast to the traditional stoichiometric us

Method for aldehyde cyanosilylation reaction under conditions of no catalyst or solvent

The invention discloses a method for an aldehyde cyanosilylation reaction under conditions of no catalyst or solvent. In a glove box, aldehyde and trimethylsilyl cyanide are sequentially added to a nuclear magnetic resonance tube, then, the glove box is m

Highly efficient oxidative cleavage of alkenes and cyanosilylation of aldehydes catalysed by magnetically recoverable MIL-101

The catalytic activity of magnetically recoverable MIL-101 was investigated in the oxidation of alkenes to carboxylic acids and cyanosilylation of aldehydes. MIL-101 was treated with Fe3O4 and the prepared catalyst was characterized using Fourier transform infrared spectroscopy, X-ray diffraction, N2 adsorption measurements, field emission scanning electron microscopy, energy-dispersive X-ray spectroscopy and inductively coupled plasma analysis. The catalytic active sites in this heterogeneous catalyst are Cr3+ nodes of the MIL-101 framework. This heterogeneous catalyst has the advantages of excellent yields, short reaction times and reusability several times without significant decrease in its initial activity and stability in both oxidation and cyanosilylation reactions. Its magnetic property allows its easy separation using an external magnetic field.

Cationic two-dimensional inorganic networks of antimony oxide hydroxide for Lewis acid catalysis

We have successfully synthesized a rare example of inorganic layered materials possessing a positive charge, which is well outside the isostructural set of layered double hydroxides. This layered architecture consists of two-dimensional corrugated [Sb2O2(OH)]+ layers with linear α,ω-alkanedisulfonate anions residing in the interlamellar space. This cationic material displays a chemical robustness under highly acidic aqueous conditions (pH = 1). Combining the robust nature and the high density of SbIII sites on the exposed crystal facets, our cationic layered material is an efficient, recyclable catalyst for cyanosilylation of benzaldehyde derivatives with trimethylsilyl cyanide. In addition, the Lewis acidity of the SbIII sites also catalyzes the ketalization of carbonyl groups under "green" solvent-free conditions.