52924-01-3

Basic information

• Product Name: 6-methoxy-1-(p-methoxyphenyl)-2-methyl-3,4-dihydronaphthalene
• CAS NO: 52924-01-3
• Molecular Weight: 280.367
• Mol File: 52924-01-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 6-methoxy-1-(p-methoxyphenyl)-2-methyl-3,4-dihydronaphthalene(CAS DataBase Reference)
• NIST Chemistry Reference: 6-methoxy-1-(p-methoxyphenyl)-2-methyl-3,4-dihydronaphthalene(52924-01-3)
• EPA Substance Registry System: 6-methoxy-1-(p-methoxyphenyl)-2-methyl-3,4-dihydronaphthalene(52924-01-3)

Safety Data

• Hazardous Substances Data: 52924-01-3(Hazardous Substances Data)

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 79-20-9 acetic acid methyl ester 
• 119047-56-2 1ζ-acetoxy-6-methoxy-2-(p-methoxyphenyl)-2-methyl-1,2,3,4-tetrahydronaphthalene 
• 31469-16-6 1-ethoxy-1-((trimethylsilyl)oxy)-2-methylpropene 
• 1078-19-9 6-methoxy-3,4-dihydro-1(2H)-naphthalenone 
• 16252-53-2 6-Methoxy-2-hydroxymethylen-1-tetralon 
• 96034-05-8 2-formyl-6-methoxy-2-(p-methoxyphenyl)-3,4-dihydronaphthalen-1(2H)-one 
• 96034-07-0 6-methoxy-2-(p-methoxyphenyl)-2-methyl-3,4-dihydronaphthalen-1(2H)-one 
• 96034-08-1 2-chloro-6-methoxy-2-methyl-3,4-dihydronaphthalen-1(2H)-one 
• 96034-06-9 6-methoxy-2-(p-methoxyphenyl)-3,4-dihydronaphthalen-1(2H)-one 
• 27752-24-5 6-methoxy-2-methyl-3,4-dihydronaphthalen-1(2H)-one 
• 96043-75-3 6-methoxy-2-(p-methoxyphenyl)-2-methyl-1,2,3,4-tetrahydronaphthalen-1ζ-ol 

Relevant articles and documents

The Structure and Function of Oestrogens. IX Synthesis of the trans Isomer of 5,5,10b-Trimethyl-4b,5,6,10b,11,12-hexahydrochrysene-2,8-diol

Alkylation of ketene methyl trimethylsilyl acetal (10) with 1ξ-acetoxy-6-methoxy-2-(p-methoxyphenyl)-2-methyl-1,2,3,4-tetrahydronaphthalene (9) in the presence of zinc iodide gave 84percent of methyl (1'RS,2'RS)-2-ethanoate (11a).Cyclization of the derived acid (11b) with methanesulfonic acid gave 89percent of 2,8-dimethoxy-10b-methyl-cis-4b,10b,11,12-tetrahydrochrysen-6(5H)-one (12a), Clemmensen reduction of which afforded 52percent of 2,8-dimethoxy-4b-methyl-cis-4b,5,6,10b,11,12-hexahydrochrysene (12b).Oxidation of (12b) with dichlorodicyanobenzoquinone gave 70percent of the conjugated enone (4), which upon hydrogenation over 10percent palladium/charcoal gave a 5:1 ratio of 2,8-dimethoxy-10b-methyl-trans-4b,10b,11,12-tetrahydrochrysen-6(5H)-one (14) and the cis isomer (12a).Exhaustive methylation of the trans ketone (14) yielded 49percent of 2,8-dimethoxy-5,5,10b-trimethyl-trans-4b,10b,11,12-tetrahydrochrysen-6(5H)-one (16), which upon Clemmensen reduction followed by O-demethylation afforded 5,5,10b-trimethyl-trans-4b,5,6,10b,11,12-hexahydrochrysene-2,8-diol (2).