529510-48-3

Upstream product

• 70030-37-4 ethyl (2-hydroxytetrahydropyran-2-yl)-acetate 
• 542-28-9 3,4,5,6-tetrahydro-2H-pyran-2-one 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 529510-37-0 ethyl (3R)-3,7-dihydroxyheptanoate 

Downstream Products

• 1188928-60-0 (3R)-7-(tert-buyldiphenylsilyloxy)-3-hydroxy-N-methoxy-N-methylheptanamide 
• 529510-50-7 [4-(tert-butyl-dimethyl-silanyloxy)-10-(tert-butyl-diphenyl-silanyloxy)-2-hydroxy-6-(4-methoxy-benzyloxy)-3-methyl-decyl]-phosphonic acid diethyl ester 
• 529510-41-6 tert-butyl (2S,3S,5R)-3-(tert-butyldimethylsiloxy)-9-(tert-butyldiphenylsiloxy)-5-(4-methoxybenzyloxy)-2-methylnonanoate 
• 1052661-41-2 3-(tert-butyl-dimethyl-silanyloxy)-9-(tert-butyl-diphenyl-silanyloxy)-5-(4-methoxy-benzyloxy)-2-methyl-nonan-1-ol 
• 529510-42-7 (2S,3S,5R)-3-(tert-Butyldimethylsiloxy)-9-(tert-butyldiphenylsiloxy)-5-(4-methoxybenzyloxy)-2-methylnonanal 
• 529510-49-4 tert-butyl (2S,3S,5R)-9-(tert-butyldiphenylsiloxy)-3-hydroxy-5-(4-methoxybenzyloxy)-2-methylnonanoate 
• 529510-40-5 tert-butyl (3S,5R)-9-(tert-butyldiphenylsiloxy)-3-hydroxy-5-(4-methoxybenzyloxy)-nonanoate 
• 529510-39-2 tert-butyl (5R)-9-(tert-butyldiphenylsiloxy)-5-(4-methoxybenzyloxy)-3-oxononanoate 
• 529510-38-1 ethyl (3R)-7-(tert-butyldiphenylsiloxy)-3-(4-methoxybenzyloxy)-heptanoate 

Relevant academic research and scientific papers

Ruthenium-SYNPHOS-catalyzed asymmetric hydrogenations: an entry to highly stereoselective synthesis of the C15-C30 subunit of dolabelide A

(Chemical Equation Presented) An efficient construction of the C15-C30 segment of the cytotoxic macrolide dolabelide A is described. The synthesis relies on ruthenium-SYNPHOS-mediated asymmetric hydrogenation reactions of β-keto esters to generate the C19, C21, and C27 hydroxyl-bearing stereocenters with very high levels of enantio- and diastereoselectivity.

Stereoselective synthesis of C15-C24 and C25-C30 fragments of dolabelides

The stereocontrolled synthesis of a C15-C24 fragment of dolabelides is reported. The C19 and C21 hydroxyl-bearing stereocenters were installed using ruthenium-mediated asymmetric hydrogenations of cyclic hemiketal 4 and β-keto ester 7. The C25-C30 portion