52980-68-4

Usage

Uses

Used in Pharmaceutical Industry:
N-(4-(METHYLAMINO)BENZOYL)-L-GLUTAMIC ACID is used as an inhibitor for human DNA methyltransferase to regulate gene expression and potentially treat diseases associated with abnormal methylation patterns, such as cancer.
Used in Cancer Research:
N-(4-(METHYLAMINO)BENZOYL)-L-GLUTAMIC ACID is used as a research tool to study the role of DNA methylation in cancer development and progression, aiding in the discovery of novel therapeutic strategies targeting this epigenetic modification.

InChI:InChI=1/C13H16N2O5/c1-14-9-4-2-8(3-5-9)12(18)15-10(13(19)20)6-7-11(16)17/h2-5,10,14H,6-7H2,1H3,(H,15,18)(H,16,17)(H,19,20)/t10-/m0/s1

Upstream product

• 38974-68-4 N-(4-iodo-benzoyl)L-glutamic acid 
• 74-89-5 methylamine 
• 56-86-0 L-glutamic acid 
• 4271-30-1 N-(4-aminobenzoyl)-L-glutamic acid 
• 357958-48-6 (S)-4-[(S)-1-Carboxy-2-(4-hydroxy-3-nitro-phenyl)-ethylcarbamoyl]-2-[(S)-4-carboxy-4-(4-methylamino-benzoylamino)-butyrylamino]-butyric acid 
• 91871-28-2 N-allyloxycarbonyl α-allyl-L-glutamate 
• 138965-46-5 3-[3-((allyloxy)carbonyl)-5-oxo-1,3-oxazolan-4-yl]propanoic acid 
• 59-05-2 N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid 

Downstream Products

• 2410-93-7 N¹⁰-methylfolic acid 
• 59-05-2 N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid 
• 25663-23-4 N-(4-{[(Ξ)-1-(2,4-diamino-pteridin-6-yl)-ethyl]-methyl-amino}-benzoyl)-L-glutamic acid 
• 97115-74-7 N-{4-[(2-amino-4-dimethylamino-pteridin-6-ylmethyl)-methyl-amino]-benzoyl}-L-glutamic acid 

Relevant academic research and scientific papers

Photohydrolysis of methotrexate produces pteridine, which induces poly-G-specific DNA damage through photoinduced electron transfer

Methotrexate (MTX), an antineoplastic agent, demonstrates phototoxicity. The mechanism of damage to biomacromolecules induced by photoirradiated MTX was examined using 32P-labeled DNA fragments obtained from a human gene. Photoirradiated MTX ca

N-Me-pAB-Glu-γ-Glu-γ-Tyr(3-NO2): An internally quenched fluorogenic γ-glutamyl hydrolase substrate

A γ-glutamyl tripeptide containing an internally quenched fluorophore has been synthesized and shown to be a substrate for recombinant rat γ-glutamyl hydrolase. HPLC, LC-MS, and fluorescence spectra support the conclusion that selective hydrolysis occurs

Efficient syntheses of pyrofolic acid and pteroyl azide, reagents for the production of carboxyl-differentiated derivatives of folic acid

Reaction of folic acid (1) with excess trifluoroacetic anhydride provides access to both the previously unknown N10-(trifluoroacetyl)pyrrofolic acid (8) and pyrofolic acid (9). Reaction of either of these materials with hydrazine selectively affords pteroyl hydrazide (13), which may be oxidized to pteroyl azide (27) on a large scale (62% overall from I without the need for chromatography). Treatment of 27 with differentially protected glutamates provides a convenient and high-yielding synthesis of differentially protected, optically pure folates.