52980-68-4

Basic information

• Product Name: N-(4-(METHYLAMINO)BENZOYL)-L-GLUTAMIC ACID
• Synonyms: (2S)-2-[(4-METHYLAMINOBENZOYL)AMINO]PENTANEDIOIC ACID;N-(4-(METHYLAMINO)BENZOYL)-L-GLUTAMIC ACID
• CAS NO: 52980-68-4
• Molecular Formula: C₁₃H₁₆N₂O₅
• Molecular Weight: 280.278
• Mol File: 52980-68-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 586.6°C at 760 mmHg
• Flash Point: 308.6°C
• Appearance: /
• Density: 1.367g/cm³
• Vapor Pressure: 1.32E-14mmHg at 25°C
• Refractive Index: 1.61
• CAS DataBase Reference: N-(4-(METHYLAMINO)BENZOYL)-L-GLUTAMIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-(METHYLAMINO)BENZOYL)-L-GLUTAMIC ACID(52980-68-4)
• EPA Substance Registry System: N-(4-(METHYLAMINO)BENZOYL)-L-GLUTAMIC ACID(52980-68-4)

Safety Data

• Hazardous Substances Data: 52980-68-4(Hazardous Substances Data)

Usage

Uses

N-[4-(Methylamino)benzoyl]-L-glutamic Acid acts as an inhibitor of human DNA methyltransferase.

InChI:InChI=1/C13H16N2O5/c1-14-9-4-2-8(3-5-9)12(18)15-10(13(19)20)6-7-11(16)17/h2-5,10,14H,6-7H2,1H3,(H,15,18)(H,16,17)(H,19,20)/t10-/m0/s1

Upstream product

• 4271-30-1 N-(4-aminobenzoyl)-L-glutamic acid 
• 138965-46-5 3-[3-((allyloxy)carbonyl)-5-oxo-1,3-oxazolan-4-yl]propanoic acid 
• 59-05-2 N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid 
• 357958-48-6 (S)-4-[(S)-1-Carboxy-2-(4-hydroxy-3-nitro-phenyl)-ethylcarbamoyl]-2-[(S)-4-carboxy-4-(4-methylamino-benzoylamino)-butyrylamino]-butyric acid 
• 56-86-0 L-glutamic acid 
• 38974-68-4 N-(4-iodo-benzoyl)L-glutamic acid 
• 74-89-5 methylamine 
• 91871-28-2 N-allyloxycarbonyl α-allyl-L-glutamate 

Downstream Products

• 2410-93-7 N¹⁰-methylfolic acid 
• 97115-74-7 N-{4-[(2-amino-4-dimethylamino-pteridin-6-ylmethyl)-methyl-amino]-benzoyl}-L-glutamic acid 
• 25663-23-4 N-(4-{[(Ξ)-1-(2,4-diamino-pteridin-6-yl)-ethyl]-methyl-amino}-benzoyl)-L-glutamic acid 
• 59-05-2 N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid 

Relevant articles and documents

Photohydrolysis of methotrexate produces pteridine, which induces poly-G-specific DNA damage through photoinduced electron transfer

Methotrexate (MTX), an antineoplastic agent, demonstrates phototoxicity. The mechanism of damage to biomacromolecules induced by photoirradiated MTX was examined using 32P-labeled DNA fragments obtained from a human gene. Photoirradiated MTX ca

Efficient syntheses of pyrofolic acid and pteroyl azide, reagents for the production of carboxyl-differentiated derivatives of folic acid

Reaction of folic acid (1) with excess trifluoroacetic anhydride provides access to both the previously unknown N10-(trifluoroacetyl)pyrrofolic acid (8) and pyrofolic acid (9). Reaction of either of these materials with hydrazine selectively affords pteroyl hydrazide (13), which may be oxidized to pteroyl azide (27) on a large scale (62% overall from I without the need for chromatography). Treatment of 27 with differentially protected glutamates provides a convenient and high-yielding synthesis of differentially protected, optically pure folates.