52987-31-2Relevant academic research and scientific papers
Discovery of RG7834: The First-in-Class Selective and Orally Available Small Molecule Hepatitis B Virus Expression Inhibitor with Novel Mechanism of Action
Han, Xingchun,Zhou, Chengang,Jiang, Min,Wang, Yongguang,Wang, Jianhua,Cheng, Zhanling,Wang, Min,Liu, Yongqiang,Liang, Chungen,Wang, Jianping,Wang, Zhanguo,Weikert, Robert,Lv, Wenzhe,Xie, Jianxun,Yu, Xin,Zhou, Xue,Luangsay, Souphalone,Shen, Hong C.,Mayweg, Alexander V.,Javanbakht, Hassan,Yang, Song
supporting information, p. 10619 - 10634 (2018/10/31)
Chronic hepatitis B virus (HBV) infection is a serious public health burden, and current therapies cannot achieve satisfactory cure rate. There are high unmet medical needs of novel therapeutic agents with differentiated mechanism of action (MOA) from the
Novel dihydroquinolizinones for the treatment and prophylaxis of hepatitis B virus infection
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, (2015/08/04)
The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4, R5 and R6 are as described herein, compositions including the compounds and methods of using the compounds.
NOVEL DIHYDROQUINOLIZINONES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION
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, (2015/09/23)
The invention provides novel compounds having the general formula (I) wherein R1, R2 R3, R4, R5 and R6 are as described herein, compositions including the compounds and methods of using the compounds in the treatment of the hepatitis B virus.
N-(α-alkylbenzylidene)-α-phenylalkylamine, its use and process for producing the same and process for producing intermediate therefor
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, (2008/06/13)
There is disclosed an N-(α-alkylbenzylidene)-α-phenylalkylamine represented by the general formula (1): STR1 wherein R1 represents a lower alkyl group, R2 represents a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group and X represents a halogen atom or a lower alkoxy group, its use and a process for producing the same and processes for producing intermediates therefor.
Application of the intramolecular ?-amidoalkylation reaction for the synthesis of 3- and 1,3-alkyl(aryl) 2-formyltetrahydroisoquinolines
Venkov,Ivanov
, p. 1707 - 1719 (2007/10/02)
3- and 1,3-alkyl(aryl) 2-formyltetrahydroisoquinolines 6 are obtained by the application of the intramolecular ?-amidoalkylation reaction from 1-alkyl(aryl)-2-arylethylformamides 2 and aldehydes in acidic medium.
