53005-47-3Relevant academic research and scientific papers
Nickel-Catalyzed Tandem Reaction of Functionalized Arylacetonitriles with Arylboronic Acids in 2-MeTHF: Eco-Friendly Synthesis of Aminoisoquinolines and Isoquinolones
Zhen, Qianqian,Chen, Lepeng,Qi, Linjun,Hu, Kun,Shao, Yinlin,Li, Renhao,Chen, Jiuxi
supporting information, p. 106 - 111 (2019/12/11)
The first example of the nickel-catalyzed tandem addition/cyclization of 2-(cyanomethyl)benzonitriles with arylboronic acids in 2-MeTHF has been developed, which provides the facile synthesis of aminoisoquinolines with good functional group tolerance under mild conditions. This chemistry has also been successfully applied to the synthesis of isoquinolones by the tandem reaction of methyl 2-(cyanomethyl)benzoates with arylboronic acids. The use of the bio-based and green solvent 2-MeTHF as the reaction medium makes the synthesis process environmentally benign. The synthetic utility of this chemistry is also indicated by the synthesis of biologically active molecules.
Cyclization Reactions of 2,3-Bis(2-cyanophenyl)propionitriles. III. Substituent Effect on the Carboanion Reactivities of the Propionitriles and Tautomerism of 5-Acetamido-11-cyanoindenoisoquinolines
Ando, Kazuo,Tokoroyama, Takashi,Kubota, Takashi
, p. 2885 - 2890 (2007/10/02)
The substituent effect in the base-catalyzed cyclization reaction of 2,3-bis(2-cyanophenyl)propionitriles (1) to 5-amino-11-cyano-11H-indenoisoquinolines has been studied and the result is discussed in terms of the dichotomic carbanion reactivities
