5301-97-3

Basic information

• Product Name: 4-(4-Methoxyphenyl)-1H-1,2,3-triazole
• Synonyms: 4-(4-Methoxyphenyl)-1H-1,2,3-triazole
• CAS NO: 5301-97-3
• Molecular Formula: C₉H₉N₃O
• Molecular Weight: 175.19
• Mol File: 5301-97-3.mol
• Article Data: 46

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(4-Methoxyphenyl)-1H-1,2,3-triazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-Methoxyphenyl)-1H-1,2,3-triazole(5301-97-3)
• EPA Substance Registry System: 4-(4-Methoxyphenyl)-1H-1,2,3-triazole(5301-97-3)

Safety Data

• Hazardous Substances Data: 5301-97-3(Hazardous Substances Data)

Upstream product

• 1777-55-5 (4-methoxyphenacylidene)triphenyl phosphorane 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 768-60-5 4-methoxyphenylacetylen 
• 4648-54-8 trimethylsilylazide 
• 6595-28-4 2-azido-1-(4-methoxyphenyl)ethan-1-one 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 
• 32117-52-5 1-(1-(4-methoxyphenyl)ethylidene)-2-tosylhydrazine 
• 3179-10-0 (E)-1-methoxy-4-(2-nitrovinyl)benzene 
• 75-52-5 nitromethane 
• 123-11-5 4-methoxy-benzaldehyde 
• 1210046-27-7 2-(4-(4-methoxyphenyl)-1H-1,2,3-triazol-1-yl)-1-phenylethan-1-one 
• 3179-10-0 1-methoxy-4-(2-nitro-vinyl)-benzene 
• 2227-57-8 3-(4-methoxyphenyl)propynoic acid 
• 60512-57-4 1-(2,2-dibromovinyl)-4-methoxybenzene 

Relevant articles and documents

Copper-Catalyzed Azide-Alkyne Cycloaddition of Hydrazoic Acid Formed in Situ from Sodium Azide Affords 4-Monosubstituted-1,2,3-Triazoles

We report a copper-catalyzed cycloaddition of hydrogen azide (hydrazoic acid, HN3) with terminal alkynes to form 4-substituted-1H-1,2,3-triazoles in a sustainable manner. Hydrazoic acid was formed in situ from sodium azide under acidic conditions to react with terminal alkynes in a copper-catalyzed reaction. Using polydentate N-donor chelating ligands and mild organic acids, the reactions were realized to proceed at room temperature under aerobic conditions in a methanol-water mixture and with 5 mol % catalyst loadings to afford 4-substituted-1,2,3-triazoles in high yields. This method is amenable on a wide range of alkyne substrates, including unprotected peptides, showing diverse functional group tolerance. It is applicable for late-stage functionalization synthetic strategies, as demonstrated in the synthesis of the triazole analogue of losartan. The preparation of orthogonally protected azahistidine from Fmoc-l-propargylglycine was realized on a gram scale. The hazardous nature of hydrazoic acid has been diminished as it forms in situ in a reactive species in the copper-catalyzed reaction.

Silica immobilized copper N-heterocyclic carbene: An effective route to 1,2,3-triazoles via azide-alkyne cycloaddition and multicomponent click reaction

A new silica supported copper N-heterocyclic carbene (Cu-NHC@SiO2) complex is prepared and characterized by scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX) and X-ray photoelectron spectroscopy (XPS) analyses. This complex is an efficient and easily retrievable catalyst for 1,2,3-triazole synthesis through direct azide-alkyne cycloaddition reaction as well as one-pot reaction using arylboronic acids. This catalytic system is also suitable for synthesis of 4-aryl-NH-1,2,3-triazoles from diverse benzaldehydes. Further, the catalyst can efficiently be recycled up to fifth cycle for all the three methods of 1,2,3-triazole synthesis through direct azide-alkyne cycloaddition and multi-component reactions.

Sulfonic acid-functionalized magnetic carbon nitride as highly efficient ionic composite for sustainable assembly of 1,2,3-triazoles

Abstract: An efficient and straightforward method for constructing of biologically active 4-aryl-NH-1,2,3-triazoles by the 1,3-dipolar cycloaddition reaction of β-nitrostyrene?and sodium azide in the presence of acidic graphitic carbon nitride (Fe3/