530141-72-1 Usage
Uses
1. Used in Pharmaceutical Industry:
Benzenepropanoic acid, 5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(2,3-dihydro-3-oxo-1,2-benzisoxazol-6-yl)methoxy]is used as a selective activator protein-1 (AP-1) inhibitor for preventing lymph node metastasis in an oral cancer model. Its ability to inhibit the DNA binding activity of c-fos/AP-1 without affecting other transcription factors makes it a promising candidate for targeted cancer therapies.
2. Used in Anti-Inflammatory Applications:
Benzenepropanoic acid, 5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(2,3-dihydro-3-oxo-1,2-benzisoxazol-6-yl)methoxy]is used as an anti-inflammatory agent, reducing the inflammatory cytokine response in lipopolysaccharide (LPS)-challenged mice. It lowers the levels of TNF-α and HMGB1 in the serum and MIP-1α and MCP-1 in the liver, which can help in managing inflammatory conditions.
3. Used in Hepatoprotective Applications:
Benzenepropanoic acid, 5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(2,3-dihydro-3-oxo-1,2-benzisoxazol-6-yl)methoxy]exhibits hepatoprotective properties, reducing in vivo necrosis of liver tissue and improving survival rates in LPS-challenged mice. This suggests its potential use in the treatment of liver diseases and conditions where liver damage is a concern.
4. Used in Anticancer Applications:
Benzenepropanoic acid, 5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(2,3-dihydro-3-oxo-1,2-benzisoxazol-6-yl)methoxy]also shows anticancer activity, reducing the proliferation and migration of HSC-3-M3 head and neck squamous carcinoma cells in vitro and the number of metastases in an HSC-3-M3 orthotopic xenograft model in vivo. This indicates its potential use in the development of novel therapeutic strategies for head and neck cancers.
Check Digit Verification of cas no
The CAS Registry Mumber 530141-72-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,3,0,1,4 and 1 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 530141-72:
(8*5)+(7*3)+(6*0)+(5*1)+(4*4)+(3*1)+(2*7)+(1*2)=101
101 % 10 = 1
So 530141-72-1 is a valid CAS Registry Number.
530141-72-1Relevant academic research and scientific papers
Synthesis technology of C-Fos/AP-1 inhibitor
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, (2019/01/08)
The invention belongs to the technical field of pharmaceutical synthesis and especially relates to a synthesis technology of a C-Fos/AP-1 inhibitor. Starting from cheap raw materials 2,4-dimethoxybenzoic acid and 2-methoxyphenylpropionic acid, acid chloride is prepared by using thionyl chloride, and a Friedel-Crafts acylation reaction is carried out under the catalysis of aluminium trichloride soas to obtain a coupled product; then, pyridine hydrobromide and sodium chloride are used to react at 160 DEG C for 30 minutes to complete the demethylation for synthesis of lactonic ring by one step,and the product can be directly used in the next reaction without purification; the cyclopentyl group is introduced by nucleophilic substitution; the lactone ring is opened to form methyl ester; afterpurification, a benzoisoxazolyl group is introduced by nucleophilic substitution, and a protecting group is taken off to prepare the final product T5224. The route of the invention is short, and onlythe Friedel-Crafts acylation, lactone ring opening and introduction of the benzoisoxazolyl group require the step of purification. The cost of the raw materials is low, and the reaction time of the process route is short. The synthesis technology is suitable for industrial production.
