53017-34-8

Upstream product

• 7446-70-0 aluminium trichloride 
• 2050-46-6 1,2-diethoxybenzene 
• 4755-77-5 Ethyl oxalyl chloride 
• 98-95-3 nitrobenzene 

Downstream Products

• 1440061-45-9 C₁₄H₁₉NO₅ 
• 1440060-05-8 C₁₉H₁₉F₂NO₃ 
• 1440059-27-7 C₁₉H₂₀ClF₂NO₃ 
• 1440062-88-3 C₁₉H₂₁F₂NO₄ 
• 1226234-80-5 C₁₂H₁₉NO₃ 
• 985-12-6 1-(3,4-diethoxybenzylidene)-6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride 
• 6298-46-0 N-(3,4-diethoxyphenylacetyl)-β-(3,4-diethoxyphenyl)ethylamine 
• 61381-04-2 2-(3,4-diethoxyphenyl)ethylamine 
• 38464-04-9 3,4-diethoxy-phenyl-acetic acid 
• 69373-87-1 ethyl 2-(3,4-diethoxyphenyl)acetate 
• 85259-39-8 ethyl 2-(3,4-diethoxyphenyl)-2-hydroxyacetate 

Relevant academic research and scientific papers

Novel method for preparing drotaverine hydrochloride intermediate

The invention discloses a novel method for preparing a drotaverine hydrochloride intermediate, belonging to the technical field of medicine synthesis. The preparation method comprises the following steps: preparing an intermediate 3,4-diethoxyphenylacetic acid with 1,2-diethoxybenzene as a raw material, and preparing the intermediate 3,4-diethoxyphenylacetamide with 3,4-diethoxyphenylacetic acid as a raw material. According to the novel process for preparing the drotaverine hydrochloride intermediate, a method for directly preparing 3,4-diethoxyphenylacetic acid and 3,4-diethoxyphenylethylamine is adopted, and a process for preparing 3,4-diethoxyphenylacetonitrile is avoided, so a reaction step of using sodium cyanide is avoided.

Design, synthesis and acaricidal/insecticidal activities of etoxazole analogues

Based on the structure-activity relationship of etoxazole analogues and benzoylphenylureas, a series of 2-(2,6-difluorophenyl)-4-(4-substitutedphenyl)- 1,3-oxazolines 4a-y were designed and synthesized. It was found that most of these compounds showed excellent acaricidal activities. They gave above 85% mortality at a concentration of 2.5 mg L-1, both for the eggs and larvae of spider mites. Some compounds also showed excellent insecticidal activities. The position and type of the substituents on the 4-phenyl of 2,4-diphenyl-1,3-oxazoline have a great influence on the activities. 2-(2,6-Difluorophenyl)-4-(2-Cl-4-(4-Cl-phenoxy)phenyl)-1,3-oxazoline (4r) exhibited 100% acaricidal mortality at 2.5 mg L-1, with 65% and 93% mortality against beet armyworm and diamondback moth, respectively, at 12.5 mg L-1, which is almost the same level as etoxazole. The newly found structure-activity relationship may also benefit further acaricide/insecticide development.