5307-07-3

Basic information

• Product Name: N-(3-Hydroxy-4-methylphenyl)acetamide
• Synonyms: N-(3-Hydroxy-4-methylphenyl)acetamide
• CAS NO: 5307-07-3
• Molecular Formula: C₉H₁₁NO₂
• Molecular Weight: 165.1891
• Mol File: 5307-07-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 368.6°Cat760mmHg
• Flash Point: 176.7°C
• Appearance: /
• Density: 1.203g/cm³
• Vapor Pressure: 5.95E-06mmHg at 25°C
• Refractive Index: 1.604
• Storage Temp.: 2-8°C
• CAS DataBase Reference: N-(3-Hydroxy-4-methylphenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-Hydroxy-4-methylphenyl)acetamide(5307-07-3)
• EPA Substance Registry System: N-(3-Hydroxy-4-methylphenyl)acetamide(5307-07-3)

Safety Data

• Hazardous Substances Data: 5307-07-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H11NO2/c1-6-3-4-8(5-9(6)12)10-7(2)11/h3-5,12H,1-2H3,(H,10,11)

Upstream product

• 103796-14-1 5-acetylamino-2-methylphenyl acetate 
• 2835-95-2 amino-4 hydroxy-2 toluene 
• 108-24-7 acetic anhydride 
• 5428-54-6 2-methyl-5-nitrophenol 
• 7732-18-5 water 
• 88867-64-5 N-(pivaloyloxy)-p-acetotoluidide 
• 6375-16-2 2-amino-4-acetylaminotoluene 

Downstream Products

• 56330-84-8 N-{4-Methyl-6-[(Z)-3-methyl-4-methylamino-phenylimino]-3-oxo-cyclohexa-1,4-dienyl}-acetamide 
• 1349821-11-9 N-[4-methyl-3-(2-phenoxyethoxy)phenyl]acetamide 
• 1349820-50-3 3-ethyl-2,6-dimethyl-7-(2-phenoxyethoxy)-1H-quinolin-4-one 
• 1175660-97-5 4-methyl-3-(2-phenoxyethoxy)phenylamine 
• 57838-79-6 N-{2-[3-Chloro-4-(2-methanesulfonylamino-ethylamino)-phenylamino]-5-hydroxy-4-methyl-phenyl}-acetamide 
• 57839-09-5 N-{2-[3-Chloro-4-(2-hydroxy-ethylamino)-phenylamino]-5-hydroxy-4-methyl-phenyl}-acetamide 
• 57839-10-8 N-[6-(3-Chloro-4-methylamino-phenylamino)-3-hydroxy-2,4-dimethyl-phenyl]-acetamide 
• 57838-77-4 N-{5-Hydroxy-2-[4-(2-hydroxy-ethylamino)-3-methyl-phenylamino]-4-methyl-phenyl}-acetamide 
• 57838-96-7 N-[2-(2-Chloro-4-methylamino-phenylamino)-5-hydroxy-4-methyl-phenyl]-acetamide 
• 57839-12-0 N-[2-(3-Chloro-4-methylamino-phenylamino)-5-hydroxy-4-methyl-phenyl]-acetamide 
• 57524-46-6 N-[2-(3-Chloro-4-ethylamino-phenylamino)-5-hydroxy-4-methyl-phenyl]-acetamide 
• 57839-07-3 N-[2-(4-Ethylamino-3-methyl-phenylamino)-5-hydroxy-4-methyl-phenyl]-acetamide 
• 57839-06-2 N-[5-Hydroxy-4-methyl-2-(3-methyl-4-methylamino-phenylamino)-phenyl]-acetamide 
• 57838-84-3 N-[2-(4-Ethylamino-phenylamino)-5-hydroxy-4-methyl-phenyl]-acetamide 

Relevant articles and documents

4(1H)-Quinolones Having Antimalarial Activity With Reduced Chemical Resistance

Provided are 4(1H)-quinolone derivatives effective in inhibiting or eliminating the viability of at least one of the stages in the life-cycle of the malarial parasite, and to show a reduced propensity to induce resistance to the compound by the target parasite. In particular, the compounds can be derivatives of phenoxyethoxy-quinolones, and including, but not only, 7-(2-phenoxyethoxy)quinolin derivatives. These compounds may be administered by themselves, with at least one other derivative compound, or with other antimalarial compounds, to an animal or human subject. The therapeutic compositions can be and formulated to reduce the extent of a Plasmodium infection in the recipient subject, or to reduce the likelihood of the onset or establishment of a Plasmodium infection if administered prior to the parasite contacting the subject. The therapeutic compositions can be formulated to provide an effective single dose amount of an antimalarial compound or multiple doses for administering over a period of time.

Hydrolysis of N-(Sulfonatooxy)-p-acetotoluidide: Solution Chemistry of Models for Carcinogenic Metabolites of Aromatic Amides

The hydrolysis reactions of the title compound, a model for the carcinogenic metabolites of polycyclic aromatic amides, were investigated over the pH range 1.0-8.0 by UV spectroscopic methods, product analyses, HPLC, and 1H NMR.This compound is unique among the N-(sulfonatooxy)acetanilides that have been studied to date in that over most of the pH range examined it exhibits non-first-order reaction kinetics.Product analyses indicate that, like the other N-(sulfonatooxy)acetanilides, the hydrolysis of this compound involves N-O bond cleavage, and the kinetics of the N-O bond cleavage process are consistent with a mechanism that includes generation of nitrenium ion-sulfate ion pairs.Four transient species, 9-12, were generated in sufficient quantity to be detected during the hydrolysis reaction.On the basis of isolated decomposition products and kinetic and spectral data obtained during the course of the hydrolysis reaction, the intermediate 9 was identified as 4-hydroxy-4-methylcyclohexa-2,5-dien-1-one N-acetylimine, while 10 and 11 were identified as the isomeric cis- and trans-N-acetyl-2-amino-5,6-dihydroxy-5-methylcyclohexa-1,3-dienes.These species are analogous to materials isolated by Gassman and Granrud from the methanolysis reactions of the methanesulfonate ester of N-hydroxy-p-acetotoluidide.The fourth intermediate, 12, has been tentatively identified as 4-(sulfonatooxy)-4-methylcyclohexa-2,5-dien-1-one.The pH dependence of the hydrolysis reactions of 9 and 10 have also been thoroughly investigated.Both are subject to acid catalysis of hydrolysis and give rise to a number of products.