N-(3-Hydroxy-4-methylphenyl)acetamide

Base Information

• Chemical Name: N-(3-Hydroxy-4-methylphenyl)acetamide
• CAS No.: 5307-07-3
• Molecular Formula: C9H11NO2
• Molecular Weight: 165.192
• Hs Code.: 2924299090
• DSSTox Substance ID: DTXSID2063767
• Nikkaji Number: J421.753E
• Wikidata: Q81990995
• Mol file: 5307-07-3.mol

Synonyms:N-(3-Hydroxy-4-methylphenyl)acetamide;5307-07-3;Acetamide, N-(3-hydroxy-4-methylphenyl)-;ACETAMIDE,N-(3-HYDROXY-4-METHYLPHENYL)-;SCHEMBL8537529;DTXSID2063767;AKOS014123158

Chemical Property of N-(3-Hydroxy-4-methylphenyl)acetamide

Chemical Property:

• Vapor Pressure: 5.95E-06mmHg at 25°C
• Boiling Point: 368.6°Cat760mmHg
• Flash Point: 176.7°C
• PSA: 52.82000
• Density: 1.203g/cm³
• LogP: 2.30850
• Storage Temp.: 2-8°C
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 165.078978594
• Heavy Atom Count: 12
• Complexity: 170

Purity/Quality:

95% ^*data from raw suppliers

N-(3-hydroxy-4-methylphenyl)acetamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C=C(C=C1)NC(=O)C)O

Technology Process of N-(3-Hydroxy-4-methylphenyl)acetamide

There total 8 articles about N-(3-Hydroxy-4-methylphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

amino-4 hydroxy-2 toluene (2835-95-2) + acetic anhydride (108-24-7) → 3-hydroxy-4-methylacetanilide (5307-07-3)

Guidance literature:

anschliessend Behandeln mit waessr.Alkali;

Reference yield:

2-methyl-5-nitrophenol (5428-54-6) → 3-hydroxy-4-methylacetanilide (5307-07-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium dithionite; aqueous NaOH-solution

2: water

With sodium hydroxide; sodium dithionite; water;

DOI:10.1021/ja01373a031

Reference yield:

N-(sulfonatooxy)-p-acetotoluidide → 4-hydroxy-4-methyl-cyclohexa-2,5-dienone (23438-23-5) + N-(2-chloro-4-methylphenyl)acetamide (18931-78-7) + 4-acetamido-2-methylphenol (16375-90-9) + 3-hydroxy-4-methylacetanilide (5307-07-3) + N-(4-hydroxymethylphenyl)acetamide (16375-88-5) + 2-(sulfonatooxy)-4-methylacetanilide

Guidance literature:

With phosphate buffer; potassium chloride; water; In acetonitrile; at 40 ℃; Rate constant; Product distribution; Mechanism; other buffers (various pH);

DOI:10.1021/jo00205a006

upstream raw materials:

2-amino-4-acetylaminotoluene

5-acetylamino-2-methylphenyl acetate

amino-4 hydroxy-2 toluene

acetic anhydride

Downstream raw materials:

amino-4 hydroxy-2 toluene

N-[4-methyl-3-(2-phenoxyethoxy)phenyl]acetamide

3-ethyl-2,6-dimethyl-7-(2-phenoxyethoxy)-1H-quinolin-4-one

4-methyl-3-(2-phenoxyethoxy)phenylamine