5310-19-0

Basic information

• Product Name: 2-[(2E)-3-(furan-2-yl)prop-2-enoyl]-1H-indene-1,3(2H)-dione
• Synonyms: 2-(3-Furan-2-yl-acryloyl)-indan-1,3-dione
• CAS NO: 5310-19-0
• Molecular Formula: C₁₀H₁₃NOS
• Molecular Weight: 266.2482
• Mol File: 5310-19-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 486.2°C at 760 mmHg
• Flash Point: 239.4°C
• Density: 1.369g/cm³
• Vapor Pressure: 1.33E-09mmHg at 25°C
• Refractive Index: 1.651
• CAS DataBase Reference: 2-[(2E)-3-(furan-2-yl)prop-2-enoyl]-1H-indene-1,3(2H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(2E)-3-(furan-2-yl)prop-2-enoyl]-1H-indene-1,3(2H)-dione(5310-19-0)
• EPA Substance Registry System: 2-[(2E)-3-(furan-2-yl)prop-2-enoyl]-1H-indene-1,3(2H)-dione(5310-19-0)

Safety Data

• Hazardous Substances Data: 5310-19-0(Hazardous Substances Data)

Usage

Appearance

Yellow crystalline

Chemical Class

Flavonoid

Biological Functions

Diverse, including anti-inflammatory, antioxidant, and anticancer effects

Occurrence

Widely distributed in plants

Applications

Precursors in synthesis of pharmaceuticals and natural products

Molecular Structure

Central indene-1,3-dione core with furan-2-ylprop-2-enoyl side chain

Interest for Research

Chemical properties make it promising for further research and potential applications in pharmaceutical and chemical industries

Upstream product

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• 74-95-3 1,1-dibromomethane 

Downstream Products

• 18879-72-6 6-Ethoxy-2-methyl-benzothiazol 

Relevant articles and documents

Consecutive and Selective Double Methylene Insertion of Lithium Carbenoids to Isothiocyanates: A Direct Assembly of Four-Membered Sulfur-Containing Cycles

A formal CH2?CH2 homologation conducted with C1 carbenoids on a carbon electrophile for the obtainment of a four-membered cycle is reported. The logic proposes the consecutive delivery of two single nucleophilic CH2 units to an isothiocyanate—as competent electrophilic partner—resulting in the assembling of a rare imino-thietane cluster. The single synthetic operation procedure documents genuine chemocontrol, as indicated by the tolerance to various reactive elements decorating the starting materials. Significantly, the double homologation protocol is accomplished directly on a carbon electrophile, thus not requiring the installation of heteroatom-centered manifolds (e.g. boron).