5310-51-0Relevant academic research and scientific papers
Synthesis of o-Nitroarylamines via Ipso Nucleophilic Substitution of Sulfonic Acids
Manne, Srinivasa Rao,Chandra, Jyoti,Mandal, Bhubaneswar
supporting information, p. 636 - 639 (2019/01/21)
A mild, efficient, and eco-friendly method for the synthesis of o-nitroarylamine from o-nitroaryl sulfonic acid via ipso nucleophilic aryl substitution by amine is described. The products have been obtained with good yields at room temperature without the assistance of any metal, activating agent, or toxic oxidant. This method is useful for racemization-free synthesis of N-aryl amino acid esters.
A general approach for the development of fluorogenic probes suitable for no-wash imaging of kinases in live cells
Zhang, Qing,Liu, Hui,Pan, Zhengying
supporting information, p. 15319 - 15322 (2015/01/08)
A general approach is presented for developing small molecule-based fluorogenic probes suitable for no-wash imaging of endogenous kinases in live cells. Probe 1, including a fluorophore-quencher system, was only turned on upon reacting with its target kinase Btk, and disclosed Btk's cellular location in live cells without any washing.
Transcription factor modulating compounds and methods of use thereof
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Page/Page column 366-367, (2008/06/13)
Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e.g., reducing antibiotic resistance and inhibiting biofilms.
Transcription factor modulating compounds and methods of use thereof
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, (2008/06/13)
Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e.g., reducing antibiotic resistance and inhibiting biofilms.
REACTIONS OF METHYL ESTERS OF N-(2,4-DINITROPHENYL)GLYCINE AND N-METHYL-N-(2,4-DINITROPHENYL)GLYCINE WITH SODIUM METHOXIDE
Machacek, Vladimir,Sterba, Vojeslav,Kolb, Ivan,Lycka, Antonin
, p. 1044 - 1052 (2007/10/02)
The reaction of methyl ester of N-(2,4-dinitrophenyl)glycine (I) with sodium methoxide produces 5-nitro-2(3H)benzimidazolone (III).The product identity has been proved by its isolation from the reaction mixture under conditions similar to those of kinetic experiments and by independent synthesis.The reaction of methyl ester of N-methyl-N-(2,4-dinitrophenyl)glycine with methoxide proceeds in two steps, the second one being substantially slower.The first step produces N-methyl-2-nitroso-4-nitroaniline (IV), which can be prepared by this reaction in good yield andpurity.N-Methyl-2-nitroso-4-nitroaniline undergoes subsequent reactions in the methoxide solutions.Products of the subsequent reactions have not been identified at the starting ester II concentrations of about 10-4 mol l-1, whereas at higher concentrations of the starting substance the reaction produces 2-amino-2'-methylamino-5,5'-dinitro-ONN-azoxybenzene (V) and 2,2'-bis(methylamino)-5,5'-dinitroazoxybenzene (VI).
