5313-35-9

Usage

Uses

Used in Biochemistry and Pharmaceutical Research:
2-methyl-1H-imidazole-4,5-dicarboxylic acid serves as a research tool in biochemistry and pharmaceuticals, utilized for studying its interactions with biological systems and its potential to influence biochemical processes.
Used in Synthesis of Biologically Active Compounds:
It is employed as a building block in the synthesis of novel biologically active compounds, contributing to the development of new pharmaceuticals and therapeutic agents.
Used as a Potential Drug Target:
2-methyl-1H-imidazole-4,5-dicarboxylic acid is considered a potential drug target for certain diseases, offering a pathway for the discovery of new treatments and interventions.
Used in Corrosion Inhibition:
2-methyl-1H-imidazole-4,5-dicarboxylic acid has been investigated for its potential as a corrosion inhibitor, which could be applied in industries where metal protection is crucial to prevent degradation and extend the lifespan of materials.
Used in Material Development:
It is also being explored for its role in the development of new materials, suggesting that it may have applications in creating innovative products with unique properties for various industries.

InChI:InChI=1/C6H6N2O4/c1-2-7-3(5(9)10)4(8-2)6(11)12/h1H3,(H,7,8)(H,9,10)(H,11,12)

Upstream product

• 615-15-6 2-Methyl-1H-benzimidazole 
• 13171-63-6 L_g-tartaric acid-dinitrate 
• 75-07-0 acetaldehyde 
• 610-20-8 di-O-nitro-tartaric acid 
• 40056-53-9 2-methyl-1H-imidazole-4,5-dicarbonitrile 
• 853791-97-6 6-hydroxy-2-methyl-1⁽³⁾H-benzimidazole-4-carboxylic acid 

Downstream Products

• 693-98-1 2-methylimidazole 
• 69579-46-0 5-chlorocarbonyl-2-methyl-1(3)H-imidazole-4-carboxylic acid 

Relevant academic research and scientific papers

Fluorescent-based solid sensor for HSO4- in water

In this report, we have shown that the encapsulation of the terbium 2-methylimidazole-4,5-dicarboxylic acid complex into inorganic host tetraethoxysilance is considered to be an efficient way for the design of anion sensors. Strong green emission still can be observed when it disperses in pure water. It was found that the luminescence of hybrid material was selectively turned off rapidly (1 s) by hydrogen sulfate compared with the addition of different anions such as F-, Cl-, Br- and I-. Thin film was successfully prepared and also could be a promising tool for recognizing HSO4-.

Preparation method of nitrogen-containing aromatic dicarboxylic acid

The invention discloses a preparation method of nitrogen-containing aromatic dicarboxylic acid. The method includes: taking quinoline, isoquinoline, benzimidazole or benzotriazole and a derivative thereof as the raw materials, adopting oxone as the oxidant, employing a metal salt as the catalyst and using inorganic acid as the medium, adding a phase transfer reagent, and carrying out reaction to obtain nitrogen-containing aromatic dicarboxylic acid. The reagents used by the method are high in stability, convenient for transportation and storage, the operation is simple, the conditions are easily controllable, and the price is low, at the same time, the catalytic effect is good, the yield is high, and waste liquid treatment is easy, therefore the method is convenient for industrial large-scale production.

Influence of Oxidation Conditions on the Yield of 2-Substituted Imidazole-4,5-dicarboxylic Acids

Conditions were found which allow 2-alkyl-substituted imidazole-4,5-dicarboxylic acids to be synthesized in preparative quantities by the oxidation of 2-alkylbenzimidazoles with hydrogen peroxide. It was shown that optimal results can be obtained at the concentration of 2-alkylimidazole in sulfuric acid of 1 M and the hydrogen peroxide: 2-alkylbenzimidazole molar ratio of 11: 1. Oxidation under these conditions results in higher yields of the target 2-alkylimidazole-4,5-dicarboxylic acids, including those with a branched alkyl group.

JAK-2 MODULATORS AND METHODS OF USE

This invention relates to the field of protein tyrosine kinases and inhibitors thereof. In particular, the invention relates to inhibitors of JAK-2, pharmaceutical compositions of the compounds for inhibiting JAK-2, methods of inhibiting JAK-2 in a cell, comprising contacting a cell in which inhibition of JAK-2 is desired with a compound or pharmaceutical composition comprising a compound according to the invention. The also comprises methods of treating a disease or condition that involves JAK-2 comprising administering to a patient a pharmaceutical composition comprising a compound according to the invention

Bis(acyloxmethyl)imidazole compounds

This invention relates to new bis(acyloxymethyl)imidazole derivatives; to compositions comprising these derivatives; and to processes for their utility as fungicides, bactericides and as inhibitors of the growth of cancer, particularly solid tumor cancer, in warm blooded animals of the formula: STR1 wherein M is STR2 or R; each R, R' and R" are independently selected from hydrogen and Z substituted or unsubstituted alkyl, cycloalkyl, cycloalkenyl, alkenyl, aryl, and heterocyclic ring wherein said ring comprises at least one of oxygen, nitrogen, sulfur or silicon; provided that STR3 may form a Z substituted or unsubstituted heterocyclic, and R' and R" attached to the imidazole ring, may form a Z substituted or unsubstituted heterocyclic ring; X is selected from at least one of oxygen, sulfur, nitrogen and alkyl; provided further that silicon is not directly attached to oxygen, sulfur or nitrogen and R' is not hydrogen when X is oxygen or sulfur; and Z is selected from halogen, nitro, nitrile, alkyl, haloalkyl, alkenyl, carboxylic acid, carboxylic acid ester, carboxylic acid amide, ether, thioether, hydroxyl, acylated hydroxyl, sulfonylamide, sulfonylurea, sulfoxide, sulfone, substituted and unsubstituted amine or mixtures thereof.

Design, Synthesis, Antineoplastic Activity, and Chemical Properties of Bis(carbamate) Derivatives of 4,5-Bis(hydroxymethyl)imidazole

A series of bis(carbamate) derivatives of 1,2-substituted 4,5-bis(hydroxymethyl)imidazoles were prepared and evaluated against murine P388 lymphocytic leukemia.Electron-withdrawing substituents at either N-1 or C-2 gave rise to inactive compounds.However, electron-donating substituents gave active compounds and the 2-(methylthio)-1-methyl derivative 2i (carmethizole), as the bis(N-methylcarbamate), was found to be very active.The derivative 2i, referred to by the name carmethizole, was also shown to be active against the MX-1 mammary xenograft, the human amelanotic melanoma cell line (LOX) xenograft, the M5076 sarcoma, and L1210 lymphocytic leukemia.The solution stability, water solubility, pKa, and log P of carmethizole are also reported.

Dinuclear Rhodium and Iridium Complexes of Dicarboxyimidazolates; Crystal Structure of *2PriOH

Dinuclear complexes of rhodium and iridium with 4,5-dicarboxyimidazole (H3dcbi) and 4,5-dicarboxy-2-methylimidazole (H3dcbmi) are reported.In each case, the bridging carboxyimidazole ligand binds as the trianion.The auxiliary ligands are cyclo-octa-1,5-diene (cod), carbon monoxide, and triphenylphosphine.The CO complexes, such as which contains a planar dinuclear anion, exhibit strong colours which are caused by intermolecular stacking interactions and which are modulated by the counter cation.The X-ray crystal structure of iOH is described.