53159-71-0

Basic information

• Product Name: 1-(2-Amino-1,3-thiazol-5-yl)ethan-1-one
• Synonyms: 1-(2-Amino-1,3-thiazol-5-yl)ethan-1-one;5-Acetyl-2-amino-1,3-thiazole;1-(2-AMinothiazol-5-yl)ethanone;1-(2-Amino-1,3-thiazol-5-yl)ethan-1-one, 2-Amino-5-ethanoyl-1,3-thiazole;2-Amino-5-acetylthiazole;1-(2-Amino-1,3-thiazol-5-yl)ethanone
• CAS NO: 53159-71-0
• Molecular Formula: C₅H₆N₂OS
• Molecular Weight: 142.17894
• Mol File: 53159-71-0.mol
• Article Data: 5

Chemical Properties

• Melting Point: 176-178 °C
• Boiling Point: 303.1±15.0 °C(Predicted)
• Appearance: /
• Density: 1.341±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 2.88±0.10(Predicted)
• CAS DataBase Reference: 1-(2-Amino-1,3-thiazol-5-yl)ethan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-Amino-1,3-thiazol-5-yl)ethan-1-one(53159-71-0)
• EPA Substance Registry System: 1-(2-Amino-1,3-thiazol-5-yl)ethan-1-one(53159-71-0)

Safety Data

• Hazardous Substances Data: 53159-71-0(Hazardous Substances Data)

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 49, p. 566, 1984 DOI: 10.1021/jo00177a042

Upstream product

• 83490-20-4 N′-carbamothioyl-N,N-dimethylformimidamide 
• 78-95-5 chloroacetone 
• 87005-15-0 α-bromoacetoacetaldehyde 
• 17356-08-0 thiourea 
• 74-89-5 methylamine 
• 96818-59-6 N,N'-bis[(dimethylamino)methylene]thiourea 

Downstream Products

• 908269-56-7 2-(2-aminothiazol-5-yl) propan-2-ol 
• 905300-56-3 tert-butyl (5-acetylthiazol-2-yl)carbamate 
• 885229-41-4 1-(2-chlorothiazol-5-yl)ethanone 
• 681138-83-0 2-[2-(3,5-difluoro-phenyl)-acetylamino]-pentanoic acid (5-acetyl-thiazol-2-yl)-amide 

Relevant articles and documents

PREPARATION OF 2-CHLORO-1-(2-CHLOROTHIAZOL-5-YL)ETHANONE

The present invention relates to a process for the preparation 2-chloro-1-(2-chlorothiazol-5-yl)ethanone.

Utilization of a nitrogen-sulfur nonbonding interaction in the design of new 2-aminothiazol-5-yl-pyrimidines as p38α MAP kinase inhibitors

The design, synthesis, and structure-activity relationships (SAR) of a series of 2-aminothiazol-5-yl-pyrimidines as novel p38α MAP kinase inhibitors are described. These efforts led to the identification of 41 as a potent p38α inhibitor that utilizes a un

THIAZOLE DERIVATIVES AND USE THEREOF

The present invention is related to thiazole derivatives of Formula (I) in particular for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, transplantation, graft rejection or lung injuries.